Immunopharmacotherapeutic advancements in addressing methamphetamine abuse,RSC Chemical Biology

当前位置： X-MOL 学术 › RSC Chem. Biol. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Immunopharmacotherapeutic advancements in addressing methamphetamine abuse
RSC Chemical Biology ( IF 4.2 ) Pub Date : 2020-10-8 , DOI: 10.1039/d0cb00165a
Jinny Claire Lee ₁ , Kim D Janda ₁

Affiliation

Methamphetamine (METH) is an illicit psychostimulant that is known to account for substance abuse disorders globally, second only to opioids, yet has no approved pharmacotherapies. Traditional therapies employ small molecule agonists or antagonists for substance use disorders or overdose reversal by targeting drug-specific receptors in the brain. However, the comprehensive mechanism of METH on multiple sites within the central nervous system (CNS) implies its receptors lack the high affinity and specificity required for an “ideal” drug target. The alternative to pharmacotherapies is to sequester abused drugs in the periphery, effectively eliminating the effects from CNS receptor occupation through pharmacokinetic antagonism. This review presents updates on immunopharmacotherapeutic advancements in addressing methamphetamine abuse by focusing on the cultivation of research optimization strategies regarding hapten chemistry, carrier proteins, and adjuvants implemented in active immunization. Furthermore, we discuss necessary developments for each component of active immunopharmacotherapies and the future of active vaccines in treating METH use disorder.

中文翻译：

解决甲基苯丙胺滥用问题的免疫药物治疗进展

甲基苯丙胺 (METH) 是一种非法精神兴奋剂，已知会导致全球药物滥用障碍，仅次于阿片类药物，但尚未获得批准的药物疗法。传统疗法采用小分子激动剂或拮抗剂，通过针对大脑中的药物特异性受体来治疗药物滥用障碍或逆转药物过量。然而，METH 在中枢神经系统 (CNS) 内多个位点的综合机制意味着其受体缺乏“理想”药物靶点所需的高亲和力和特异性。药物疗法的替代方案是将滥用的药物隔离在外周，通过药代动力学拮抗作用有效消除中枢神经系统受体占用的影响。本综述通过重点培养有关主动免疫中实施的半抗原化学、载体蛋白和佐剂的研究优化策略，介绍了解决甲基苯丙胺滥用问题的免疫药物治疗进展的最新进展。此外，我们还讨论了主动免疫药物疗法各个组成部分的必要发展以及主动疫苗治疗冰毒使用障碍的未来。

更新日期：2020-12-10

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文