Sulforaphane attenuates hexavalent chromium-induced cardiotoxicity via the activation of the Sesn2/AMPK/Nrf2 signaling pathway,Metallomics

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Sulforaphane attenuates hexavalent chromium-induced cardiotoxicity via the activation of the Sesn2/AMPK/Nrf2 signaling pathway
Metallomics ( IF 2.9 ) Pub Date : 2020-10-8 , DOI: 10.1039/d0mt00124d
Daqian Yang ₁ , Bing Han , Ruiqi Baiyun , Zhanjun Lv , Xiaoqiao Wang , Siyu Li , Yueying Lv , Jiangdong Xue , Yan Liu , Zhigang Zhang

Affiliation

Hexavalent chromium (Cr(VI)), the most toxic valence state of chromium, is widely present in industrial effluents and wastes. Sulforaphane (SFN), rich in Brassica genus plants, bears multiple biological activity. Wistar rats were used to explore the protective role of SFN against the cardiotoxicity of chronic potassium dichromate (K₂Cr₂O₇) exposure and reveal the potential molecular mechanism. The data showed that SFN alleviated hematological variations, oxidative stress, heart dysfunction and structure disorder, and cardiomyocyte apoptosis induced by K₂Cr₂O₇. Moreover, SFN reduced p53, cleaved caspase-3, Bcl2-associated X protein, nuclear factor kappa-B, and interleukin-1β levels, and increased Sesn2, nuclear factor erythroid 2-related factor 2 (Nrf2), heme oxygenase-1, NAD(P)H quinone oxidoreductase-1, and phosphorylated adenosine 5′-monophosphate (AMP)-activated protein kinase (AMPK) levels. This study demonstrates that SFN ameliorates Cr(VI)-induced cardiotoxicity via activation of the Sesn2/AMPK/Nrf2 signaling pathway. SFN may be a protector against Cr(VI)-induced heart injury and a novel therapy for chronic Cr(VI) exposure.

中文翻译：

萝卜硫素通过激活 Sesn2/AMPK/Nrf2 信号通路减弱六价铬诱导的心脏毒性

六价铬 (Cr( VI )) 是铬的最具毒性的价态，广泛存在于工业废水和废物中。萝卜硫素（SFN）富含芸苔属植物，具有多种生物活性。Wistar大鼠用于探索SFN对慢性重铬酸钾（K ₂ Cr ₂ O ₇）暴露心脏毒性的保护作用并揭示潜在的分子机制。数据表明，SFN可减轻K ₂ Cr ₂ O _{7诱导的血液学变异、氧化应激、心脏功能障碍和结构紊乱以及心肌细胞凋亡。}. 此外，SFN 降低 p53、裂解的 caspase-3、Bcl2 相关 X 蛋白、核因子 kappa-B 和白细胞介素 1β 水平，并增加 Sesn2、核因子红细胞 2 相关因子 2 (Nrf2)、血红素加氧酶 1、 NAD(P)H 醌氧化还原酶-1 和磷酸化腺苷 5'-一磷酸 (AMP) 活化蛋白激酶 (AMPK) 水平。本研究表明，SFN通过激活 Sesn2/AMPK/Nrf2 信号通路改善 Cr( VI ) 诱导的心脏毒性。SFN 可能是防止 Cr( VI ) 引起的心脏损伤的保护剂和慢性 Cr( VI ) 暴露的新疗法。

更新日期：2020-10-08

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