Most individuals undergo traumatic stresses at some points in their life, but only a small proportion develop stress-related disorders such as anxiety diseases and posttraumatic stress disorder (PTSD). Although stress susceptibility is one determinant of mental disorders, the underlying mechanisms and functional implication remain unclear yet. We found that an increased amount of freezing that animals exhibited in the intertrial interval (ITI) of a stress-enhanced fear learning paradigm, predicts ensuing PTSD-like symptoms whereas resilient mice show ITI freezing comparable to that of unstressed mice. To examine the behavioral features, we developed a systematic analytical approach for ITI freezing and stress susceptibility. Thus, we provide a behavioral parameter for prognosis to stress susceptibility of individuals in the development of PTSD-like symptoms as well as a new mathematical means to scrutinize freezing behavior.

中文翻译：

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基于恐惧反应的 PTSD 类表型应激易感性预测


大多数人在一生中的某些时刻都会经历创伤性压力，但只有一小部分人会患上与压力相关的疾病，例如焦虑症和创伤后应激障碍（PTSD）。尽管应激敏感性是精神障碍的决定因素之一，但其潜在机制和功能意义仍不清楚。我们发现，动物在压力增强的恐惧学习范​​式的间歇期（ITI）中表现出的冻结程度增加，可以预测随后出现的类似 PTSD 的症状，而有弹性的小鼠则表现出与无压力小鼠相当的 ITI 冻结。为了检查行为特征，我们开发了一种 ITI 冻结和应激敏感性的系统分析方法。因此，我们提供了一个行为参数，用于预测个体在发生 PTSD 样症状时的应激易感性，以及一种新的数学方法来检查冻结行为。