Objective:

Frontal behaviors (i.e., executive dysfunction, disinhibition, apathy) are common in Parkinson’s disease (PD). However, it is unclear if patient and informant reports of patient frontal behaviors are in agreement over time.

Method:

Sixty-two PD patients without dementia and their informants (87% spouses/partners) completed the self- and informant-versions of the Frontal Systems Behavior Scale at baseline and 2-year follow-up. Dyad ratings were compared and predictors of behavior ratings were examined.

Results:

Patient and informant reports at baseline and follow-up were in agreement, with significant increases in overall frontal behaviors, executive dysfunction, and apathy. Higher levels of baseline patient depression and caregiver burden predicted decrements in patient-reported executive function; worse patient cognition at baseline predicted worsening apathy as rated by informants.

Conclusions:

PD patients and their informants are concordant in their ratings of worsening frontal behaviors over time. Targeting patient depression, cognition, and caregiver burden may improve decrements in frontal behaviors (executive dysfunction and apathy) in PD.

中文翻译：

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帕金森病中自我和知情人报告的额叶行为的变化：一项纵向研究

客观的：

前额行为（即执行功能障碍、去抑制、冷漠）在帕金森病 (PD) 中很常见。然而，随着时间的推移，尚不清楚患者和知情人对患者正面行为的报告是否一致。

方法：

62 名无痴呆的 PD 患者及其知情人（87% 的配偶/伴侣）在基线和 2 年随访时完成了额叶系统行为量表的自我和知情人版本。对二元评级进行了比较，并检查了行为评级的预测因素。

结果：

基线和随访时的患者和知情人报告一致，整体正面行为、执行功能障碍和冷漠显着增加。较高水平的基线患者抑郁和照顾者负担预示着患者报告的执行功能下降；基线时较差的患者认知预示着信息提供者评估的冷漠恶化。

结论：

PD 患者及其知情人对随时间恶化的额叶行为的评分是一致的。针对患者抑郁、认知和照顾者负担可能会改善 PD 中额叶行为（执行功能障碍和冷漠）的减少。