Objectives:

To understand the differential neuroanatomical substrates underlying apathy and depression in Frontotemporal dementia (FTD).

Methods:

T1-MRIs and clinical data of patients with behavioral and aphasic variants of FTD were obtained from an open database. Cortical thickness was derived, its association with apathy severity and difference between the depressed and not depressed were examined with appropriate covariates.

Results:

Apathy severity was significantly associated with cortical thinning of the lateral parts of the right sided frontal, temporal and parietal lobes. The right sided orbitofrontal, parsorbitalis and rostral anterior cingulate cortex were thicker in depressed compared to patients not depressed.

Conclusions:

Greater thickness of right sided ventromedial and inferior frontal cortex in depression compared to patients without depression suggests a possible requisite of gray matter in this particular area for the manifestation of depression in FTD. This study demonstrates a method for deriving neuroanatomical patterns across non-harmonized neuroimaging data in a neurodegenerative disease.

中文翻译：

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额颞叶痴呆患者的抑郁与保留的皮质厚度相关，而冷漠则与抑郁相关

 目标：

了解额颞叶痴呆 (FTD) 冷漠和抑郁背后的不同神经解剖学基础。

 方法：

FTD 行为和失语变异患者的 T1-MRI 和临床数据是从开放数据库中获得的。得出皮质厚度，并用适当的协变量检查其与冷漠严重程度的关系以及抑郁症和非抑郁症之间的差异。

 结果：

冷漠的严重程度与右侧额叶、颞叶和顶叶外侧部分的皮质变薄显着相关。与非抑郁症患者相比，抑郁症患者的右侧眶额皮质、眶旁肌和吻侧前扣带皮层更厚。

 结论：

与非抑郁症患者相比，抑郁症患者的右侧腹内侧皮质和下额皮质厚度更大，这表明该特定区域的灰质可能是 FTD 抑郁症表现所必需的。这项研究展示了一种通过神经退行性疾病的非统一神经影像数据得出神经解剖模式的方法。