Sarcoidosis is a rare disease characterized by granulomatous inflammation in affected organs, primarily in lungs. Neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR) are easy and practical methods providing valuable information in diagnosis, severity, and prognosis of various diseases. Here, we aimed to investigate the association between NLR, PLR, and hematological parameters in sarcoidosis. The study was performed with 75 sarcoidosis patients and 92 controls. Patients’ NLR, PLR, and hematological parameters were compared with those of controls. Additionally, while differences between NLR and PLR were investigated in sarcoidosis patients, differences of extrapulmonary involvement, pulmonary hypertension (PH), and spontaneous remission between those with and without responses to treatment concerning stages were also assessed. NLR and PLR were significantly higher in sarcoidosis patients than controls. For NLR, sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were found as 68, 61, 58, and 70% respectively, while sensitivity, specificity, PPV, and NPV for PLR were found as 72, 67, 63, and 74%, respectively. In sarcoidosis patients, NLR and PLR were significantly higher at stage-2 and -3 than at stage -1 and -4. There was a significant weak positive correlation between C-reactive protein (CRP) and NLR and PLR. Mean platelet volume (MPV), hemoglobin (Hgb), and mean corpuscular volume (MCV) were lower among patients than controls. A positive moderate correlation was detected between NLR and CD4/CD8 in blood, while there was a strong positive correlation between CD4/CD8 in bronchoalveolar lavage (BAL) and positive moderate correlation between PLR and CD4/CD8 in BAL. High NLR and PLR values were not significantly associated with pulmonary PH, spontaneous remission, response to treatment, and prognosis. The increase in PLR and NLR may be a guide for diagnoses of both sarcoidosis and lung parenchymal involvement. To use these entities as markers, our findings should be supported with prospective studies with larger samples.

中文翻译：

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中性粒细胞/淋巴细胞和血小板/淋巴细胞比率以及血液学参数与结节病患者的诊断、分期、肺外受累、肺动脉高压、治疗反应和预后的关系

结节病是一种罕见疾病，其特征是受影响器官（主要是肺部）出现肉芽肿性炎症。中性粒细胞/淋巴细胞比值（NLR）和血小板/淋巴细胞比值（PLR）是简单实用的方法，为各种疾病的诊断、严重程度和预后提供有价值的信息。在这里，我们的目的是研究结节病中 NLR、PLR 和血液学参数之间的关联。该研究针对 75 名结节病患者和 92 名对照者进行。将患者的 NLR、PLR 和血液学参数与对照组进行比较。此外，虽然在结节病患者中研究了 NLR 和 PLR 之间的差异，但还评估了对有关阶段的治疗有反应和无反应的患者之间肺外受累、肺动脉高压（PH）和自发缓解的差异。结节病患者的 NLR 和 PLR 显着高于对照组。NLR 的敏感性、特异性、阳性预测值 (PPV) 和阴性预测值 (NPV) 分别为 68%、61%、58% 和 70%，而 PLR 的敏感性、特异性、PPV 和 NPV 为 72% 、 67%、63% 和 74%。在结节病患者中，2期和-3期的NLR和PLR显着高于-1期和-4期。C反应蛋白（CRP）与NLR、PLR呈显着的弱正相关。患者的平均血小板体积（MPV）、血红蛋白（Hgb）和平均红细胞体积（MCV）低于对照组。血液中 NLR 与 CD4/CD8 呈中度正相关，支气管肺泡灌洗液 (BAL) 中 CD4/CD8 呈强正相关，BAL 中 PLR 与 CD4/CD8 呈中度正相关。高 NLR 和 PLR 值与肺 PH、自发缓解、治疗反应和预后没有显着相关性。PLR 和 NLR 的增加可能可以指导结节病和肺实质受累的诊断。为了使用这些实体作为标记，我们的发现应该得到更大样本的前瞻性研究的支持。