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B Cell Immunosenescence
Annual Review of Cell and Developmental Biology ( IF 11.4 ) Pub Date : 2020-10-06 , DOI: 10.1146/annurev-cellbio-011620-034148
Daniela Frasca 1, 2, 3 , Alain Diaz 1 , Maria Romero 1 , Denisse Garcia 1 , Bonnie B Blomberg 1, 2
Affiliation  

Innate and adaptive immune responses decline with age, leading to greater susceptibility to infectious diseases and reduced responses to vaccines. Diseases are more severe in old than in young individuals and have a greater impact on health outcomes such as morbidity, disability, and mortality. Aging is characterized by increased low-grade chronic inflammation, so-called inflammaging, that represents a link between changes in immune cells and a number of diseases and syndromes typical of old age. In this review we summarize current knowledge on age-associated changes in immune cells with special emphasis on B cells, which are more inflammatory and less responsive to infections and vaccines in the elderly. We highlight recent findings on factors and pathways contributing to inflammaging and how these lead to dysfunctional immune responses. We summarize recent published studies showing that adipose tissue, which increases in size with aging, contributes to inflammaging and dysregulated B cell function.

中文翻译:


B细胞免疫衰老

先天性和适应性免疫反应随着年龄的增长而下降,导致对传染病的易感性增加,对疫苗的反应降低。老年人的疾病比年轻人更严重,对健康结果(例如发病率、残疾和死亡率)的影响更大。衰老的特点是低度慢性炎症增加,即所谓的炎症,这代表了免疫细胞的变化与老年典型的许多疾病和综合征之间的联系。在这篇综述中,我们总结了目前关于免疫细胞年龄相关变化的知识,特别强调 B 细胞,这些细胞更具炎症性,对老年人感染和疫苗的反应较差。我们重点介绍了有关导致炎症的因素和途径的最新发现,以及这些因素和途径如何导致免疫反应功能失调。

更新日期:2020-10-08
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