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The Lineage Before Time: Circadian and Nonclassical Clock Influences on Development
Annual Review of Cell and Developmental Biology ( IF 11.4 ) Pub Date : 2020-10-06 , DOI: 10.1146/annurev-cellbio-100818-125454
Joseph Lewis Bedont 1 , Daniel Maxim Iascone 1 , Amita Sehgal 1, 2
Affiliation  

Diverse factors including metabolism, chromatin remodeling, and mitotic kinetics influence development at the cellular level. These factors are well known to interact with the circadian transcriptional-translational feedback loop (TTFL) after its emergence. What is only recently becoming clear, however, is how metabolism, mitosis, and epigenetics may become organized in a coordinated cyclical precursor signaling module in pluripotent cells prior to the onset of TTFL cycling. We propose that both the precursor module and the TTFL module constrain cellular identity when they are active during development, and that the emergence of these modules themselves is a key lineage marker. Here we review the component pathways underlying these ideas; how proliferation, specification, and differentiation decisions in both developmental and adult stem cell populations are or are not regulated by the classical TTFL; and emerging evidence that we propose implies a primordial clock that precedes the classical TTFL and influences early developmental decisions.

中文翻译:



时间之前的谱系:昼夜节律和非经典时钟对发育的影响



新陈代谢、染色质重塑和有丝分裂动力学等多种因素影响细胞水平的发育。众所周知,这些因素在昼夜节律转录翻译反馈环(TTFL)出现后会与其相互作用。然而,直到最近才变得清楚的是,在 TTFL 循环开始之前,代谢、有丝分裂和表观遗传学如何在多能细胞中的协调循环前体信号模块中组织起来。我们认为,前体模块和 TTFL 模块在发育过程中活跃时都会限制细胞身份,并且这些模块本身的出现是一个关键的谱系标记。在这里,我们回顾一下这些想法背后的组成途径;发育干细胞群和成体干细胞群的增殖、规范和分化决策如何受或不受经典 TTFL 的调节;我们提出的新证据表明存在一个先于经典 TTFL 并影响早期发育决策的原始时钟。

更新日期:2020-10-08
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