The Dendropanax genus is a kind of flowering plant in the family of Araliaceae that encompasses approximately 91 to 95 species. Several Dendropanax species are used as traditional medicinal plants, extensively used Korea and South America and other parts of the world. Almost every part of the plant, including the leaves, bark, roots, and stems, can be used as traditional medicine for the prevention and management of a broad spectrum of health disorders. This paper sought to summarizes the ethnopharmacological benefits, biological activities, and phytochemical investigations of plants from the genus Dendropanax, and perhaps to subsequently elucidate potential new perspectives for future pharmacological research to consider. Modern scientific literature suggests that plants of the Dendropanax genus, together with active compounds isolated from it, possess a wide range of therapeutic and pharmacological applications, including antifungal, anti-complement, antioxidant, antibacterial, insect antifeedant, cytotoxic, anti-inflammatory, neuroprotective, anti-diabetic, anti-cancer, and anti-hypouricemic properties. The botanical descriptions of approximately six to 10 species are provided by different scientific web sources. However, only six species, namely, D. morbiferus, D. gonatopodus, D. dentiger, D. capillaris, D. chevalieri, and D. arboreus, were included in the present investigation to undergo phytochemical evaluation, due to the unavailability of data for the remaining species. Among these plant species, a high concentration of variable bioactive ingredients was identified. In particular, D. morbifera is a traditional medicinal plant used for the multiple treatment purposes and management of several human diseases or health conditions. Previous experimental evidence supports that the D. morbifera species could be used to treat various inflammatory disorders, diarrhea, diabetes, cancer, and some microbial infections. It has recently been reported, by our group and other researchers, that D. morbifera possesses a neuroprotective and memory-enhancing agent. A total of 259 compounds have been identified among six species, with 78 sourced from five of these species reported to be bioactive. However, there is no up-to-date information concerning the D. morbifera, its different biological properties, or its prospective benefits in the enhancement of human health. In the present study, we set out to conduct a comprehensive analysis of the botany, traditional medicinal history, and medicinal resources of species of the Dendropanax genus. In addition, we explore several phytochemical constituents identified in different species of the Dendropanax genus and their biological properties. Finally, we offer comprehensive analysis findings of the phytochemistry, medicinal uses, pharmacological actions, and a toxicity and safety evaluation of the D. morbifera species and its main bioactive ingredients for future consideration.

中文翻译：

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Dendropanax Morbiferus和Dendropanax属的其他物种：其传统用途，植物化学和药理学的治疗潜力

该树参属是一种在五加科的，它包括大约91至95种开花植物。Dendropanax的几种物种被用作传统药用植物，广泛用于韩国和南美以及世界其他地区。植物的几乎每个部分，包括叶子，树皮，根和茎，都可以用作预防和管理各种健康疾病的传统药物。本文试图总结Dendropanax属植物的民族药理作用，生物学活性和植物化学研究，并可能随后阐明将来药理学研究需要考虑的潜在新观点。现代科学文献表明，Dendropanax属植物及其分离出的活性化合物具有广泛的治疗和药理应用，包括抗真菌，抗补体，抗氧化剂，抗菌，昆虫拒食，细胞毒性，抗炎，神经保护，抗糖尿病，抗癌和抗潮血性。不同的科学网络资源提供了大约6至10种植物的描述。然而，只有6种，分别是D. morbiferus，D. gonatopodus，D. dentiger，D.茵陈，D.谢瓦，和由于无法获得其余物种的数据，本研究中包括了D. arboreus进行植物化学评估。在这些植物物种中，鉴定出高浓度的可变生物活性成分。尤其是，D。morbifera是一种传统的药用植物，用于多种治疗目的和多种人类疾病或健康状况的管理。先前的实验证据表明，D。morbifera种可用于治疗各种炎症性疾病，腹泻，糖尿病，癌症和某些微生物感染。我们的小组和其他研究人员最近报告说，D。morbifera具有神经保护和记忆增强剂。在六个物种中共鉴定出259种化合物，其中78种来自其中五个物种，据报道具有生物活性。但是，没有关于D. morbifera，其不同的生物学特性或其在增强人类健康方面的预期益处的最新信息。在本研究中，我们着手对Dendropanax属的植物学，传统医学史和药用资源进行全面分析。此外，我们探索了在Dendropanax的不同物种中鉴定出的几种植物化学成分属及其生物学特性。最后，我们提供了关于D. morbifera物种及其主要生物活性成分的植物化学，药物用途，药理作用以及毒性和安全性评估的综合分析结果，以供将来考虑。