Abstract

An efficient and straightforward procedure has been developed for the synthesis of 2-amino-3-cyano-4H-pyrans via the one-pot three-component reaction of benzaldehydes, malononitrile and 1,3-dicarbonyl compounds using a new nanomagnetite-supported organocatalyst (MNP@PEG-ImOH) in aqueous media. The MNPs are fully characterized by various techniques including Fourier transform infrared spectroscopy (FT-IR), field-emission scanning electron microscopy (FESEM), energy-dispersive X-ray (EDAX), transmission electron microscopy (TEM), thermogravimetric analysis (TGA), X-ray diffraction (XRD), and vibrating sample magnetometry (VSM). The catalyst could readily be separated from the reaction mixture using an external magnet and could be reused in subsequent runs without a notable decrease of activity.

摘要

已开发出一种有效且直接的方法用于通过以下途径合成 2-氨基-3-氰基-4 H-吡喃使用新型纳米磁铁负载有机催化剂 (MNP@PEG-ImOH) 在水介质中进行苯甲醛、丙二腈和 1,3-二羰基化合物的一锅三组分反应。MNPs 通过各种技术进行全面表征，包括傅里叶变换红外光谱 (FT-IR)、场发射扫描电子显微镜 (FESEM)、能量色散 X 射线 (EDAX)、透射电子显微镜 (TEM)、热重分析 (TGA) )、X 射线衍射 (XRD) 和振动样品磁强计 (VSM)。催化剂可以很容易地使用外部磁铁从反应混合物中分离出来，并且可以在后续运行中重复使用，而不会显着降低活性。