Abstract An efficient one-pot three-component Kabachnik–Fields reaction of aldehydes (acyclic nucleosides), amines (or amino acid), and triethyl phosphite proceeded for the synthesis of aminophosphonates using natural phosphate coated with iodine (I2@NP) as a catalyst. The novel α-aminophosphonate and phosphonic acid acyclic nucleosides were tested for their anti-HCV and anti-HIV activities. The molecular docking showed that the non-activity of these compounds could be due to the absence of hydrophobic pharmacophores.

中文翻译：

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制备新型α-氨基膦酸酯和膦酸无环核苷的高效一锅三组分程序

摘要 醛（无环核苷）、胺（或氨基酸）和亚磷酸三乙酯的高效一锅三组分 Kabachnik-Fields 反应用于合成氨基膦酸酯，使用碘包覆的天然磷酸盐 (I2@NP) 作为催化剂. 测试了新型 α-氨基膦酸酯和膦酸无环核苷的抗 HCV 和抗 HIV 活性。分子对接表明，这些化合物的非活性可能是由于不存在疏水性药效团。