ABSTRACT

Heart and cerebral infarctions, as two important ischemic diseases, lead to the death of tissues due to inadequate blood supply and high mortality worldwide. These statuses are started via blockage of vessels and depletion of oxygen and nutrients which affected these areas. After reperfusion and restoration of oxygen supply, more severe injury was mediated by multifaceted cascades of inflammation and oxidative stress. microRNAs (miRNAs) as the regulator of biological and pathological pathways can adjust these conditions by interaction with their targets. Also, miRNAs can be modulated by preconditioning and external agents that may improve the functional outcome after IRI. miRNAs might be considered as therapeutic approaches to improve the symptoms of patients after myocardial infarction and cerebral ischemic stroke.

摘要

心梗和脑梗作为两种重要的缺血性疾病，在世界范围内因供血不足和高死亡率导致组织死亡。这些状态是通过血管阻塞以及影响这些区域的氧气和营养物质的消耗开始的。再灌注和恢复供氧后，炎症和氧化应激的多方面级联介导了更严重的损伤。microRNAs (miRNAs) 作为生物和病理途径的调节剂，可以通过与其靶标相互作用来调节这些条件。此外，miRNA 可以通过预处理和外部试剂进行调节，从而改善 IRI 后的功能结果。miRNA可能被认为是改善心肌梗塞和脑缺血性卒中患者症状的治疗方法。