ABSTRACT

Introduction

Once pulmonary disease progresses to end-stage pulmonary disease, treatment options are very limited. An important advance in the field is the development of a bioartificial lung derived from a generic matrix scaffold populated with patients’ own cells. Significant progress has already been made in the engineering of bioartificial lungs.

Areas covered

This review explains how previous and current research contributes to the goal of creating a successful bioartificial lung, and the barriers faced in doing so. We will also highlight some of the design considerations being explored to optimize bioartificial lungs and considerations for clinical translation.

Expert opinion

While current bioartificial lungs are able to provide short-term gas exchange in large-animal studies, much work is still required to combine the disciplines of cell biology, materials science, and tissue engineering to create such clinically useful and functioning artificial lungs.

中文翻译：

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生物工程肺——现状和未来前景

摘要

介绍

一旦肺病发展为终末期肺病，治疗选择就非常有限。该领域的一个重要进展是开发了一种生物人工肺，该肺来源于填充有患者自身细胞的通用基质支架。生物人工肺的工程化已经取得重大进展。

覆盖区域

这篇综述解释了以前和当前的研究如何为创建成功的生物人工肺的目标做出贡献，以及这样做所面临的障碍。我们还将重点介绍一些正在探索的优化生物人工肺的设计考虑因素以及临床转化的考虑因素。

专家意见

虽然目前的生物人工肺能够在大型动物研究中提供短期气体交换，但仍需要做很多工作来结合细胞生物学、材料科学和组织工程学科，以创建这种临床有用且功能强大的人工肺。