Abstract

Spray dried molecular inclusion complexes of starch with paracetamol, were produced using an industrial-scale spray drying unit. X-ray diffraction (XRD), Differential Scanning Calorimetry (DSC), Optical Microscopy and Confocal Laser Scanning Microscopy (CLSM) were applied to investigate the structure and morphology of the spray dried products. Physical properties: tapped and bulk densities, flowability, cohesiveness, water solubility, particle size distribution, suspensibility and hygroscopicity, were also determined. All spray dried powders exhibited good functional characteristics. XRD and DCS analysis revealed that the complexes were in an amorphous state rather than in a crystalline one. Microscopic examination indicated the presence of the drug molecules inside the amylose helices. The particulate form of the spray dried powders studded with hollow cavities was indicative of their porous structure. The experimental results indicated that the spray drying technique is suitable for the production of starch molecular inclusion complexes with enhanced functional properties.

摘要

淀粉与扑热息痛的喷雾干燥分子包合物是使用工业规模的喷雾干燥装置生产的。应用 X 射线衍射 (XRD)、差示扫描量热法 (DSC)、光学显微镜和共聚焦激光扫描显微镜 (CLSM) 来研究喷雾干燥产品的结构和形貌。物理特性：振实和堆积密度、流动性、内聚性、水溶性、粒度分布、悬浮性和吸湿性也被确定。所有喷雾干燥粉末都表现出良好的功能特性。XRD 和 DCS 分析表明配合物处于非晶态而不是结晶态。显微镜检查表明直链淀粉螺旋内存在药物分子。散布有空腔的喷雾干燥粉末的颗粒形式表明它们的多孔结构。实验结果表明，喷雾干燥技术适用于生产具有增强功能特性的淀粉分子包合物。