Abstract The initial colonization of the host organism by commensal, probiotic, and pathogenic Escherichia coli strains is an important step in the development of infections and biofilms. Sensing and colonization of host cell surfaces are governed by flagellar and fimbriae/pili appendages, respectively. Biofilm formation confers great advantages on pathogenic E. coli cells such as protection against the host immune system, antimicrobial agents, and several environmental stress factors. The transition from planktonic to sessile physiological states involves several signaling cascades and factors responsible for the regulation of flagellar motility in E. coli cells. These regulatory factors have thus become important targets to control pathogenicity. Hence, attenuation of flagellar motility is considered a potential therapy against pathogenic E. coli. The present review describes signaling pathways and proteins involved in direct or indirect regulation of flagellar motility. Furthermore, application strategies for antimotility natural or synthetic compounds are discussed also.

中文翻译：

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参与大肠杆菌细胞运动调节的分子：综述

摘要 共生、益生菌和致病性大肠杆菌菌株对宿主生物的初始定植是感染和生物膜发展的重要步骤。宿主细胞表面的感知和定植分别由鞭毛和菌毛/菌毛附属物控制。生物膜的形成为致病性大肠杆菌细胞带来了巨大的优势，例如针对宿主免疫系统、抗菌剂和几种环境压力因素的保护。从浮游到固着生理状态的转变涉及几个信号级联和负责调节大肠杆菌细胞鞭毛运动的因素。这些调节因子因此成为控制致病性的重要目标。因此，鞭毛运动的减弱被认为是对抗致病性大肠杆菌的潜在疗法。大肠杆菌。本综述描述了参与鞭毛运动直接或间接调节的信号通路和蛋白质。此外，还讨论了抗动力天然或合成化合物的应用策略。