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N 6 ‐methyladenosine (m 6 A) RNA modification in human cancer
Cell Proliferation ( IF 5.9 ) Pub Date : 2020-10-07 , DOI: 10.1111/cpr.12921 Fu-Chun Huo 1 , Zhi-Man Zhu 1 , Dong-Sheng Pei 1
Cell Proliferation ( IF 5.9 ) Pub Date : 2020-10-07 , DOI: 10.1111/cpr.12921 Fu-Chun Huo 1 , Zhi-Man Zhu 1 , Dong-Sheng Pei 1
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N6‐methyladenosine (m6A) RNA modification, first discovered in 1974, is the most prevalent, abundant and penetrating messenger RNA (mRNA) modification in eukaryotes. This governs the fate of modified transcripts, regulates RNA metabolism and biological processes, and participates in pathogenesis of numerous human diseases, especially in cancer through the reciprocal regulation of m6A methyltransferases (“writers”) and demethylases (“erasers”) and the binding proteins decoding m6A methylation (“readers”). Accumulating evidence indicates a complicated regulation network of m6A modification involving multiple m6A‐associated regulatory proteins whose biological functions have been further analysed. This review aimed to summarize the current knowledge on the potential significance and molecular mechanisms of m6A RNA modification in the initiation and progression of cancer.
中文翻译：
人类癌症中的 N 6-甲基腺苷 (m 6 A) RNA 修饰
N6-甲基腺苷 (m6A) RNA 修饰于 1974 年首次发现，是真核生物中最普遍、最丰富和最具穿透性的信使 RNA (mRNA) 修饰。这控制着修饰转录物的命运，调节 RNA 代谢和生物过程，并通过相互调节 m6A 甲基转移酶（“写入器”）和去甲基化酶（“擦除器”）和结合蛋白参与许多人类疾病的发病机制，尤其是癌症解码 m6A 甲基化（“阅读器”）。越来越多的证据表明，m6A 修饰的复杂调控网络涉及多个 m6A 相关调控蛋白，其生物学功能已得到进一步分析。
更新日期：2020-10-07
中文翻译：
人类癌症中的 N 6-甲基腺苷 (m 6 A) RNA 修饰
N6-甲基腺苷 (m6A) RNA 修饰于 1974 年首次发现，是真核生物中最普遍、最丰富和最具穿透性的信使 RNA (mRNA) 修饰。这控制着修饰转录物的命运，调节 RNA 代谢和生物过程，并通过相互调节 m6A 甲基转移酶（“写入器”）和去甲基化酶（“擦除器”）和结合蛋白参与许多人类疾病的发病机制，尤其是癌症解码 m6A 甲基化（“阅读器”）。越来越多的证据表明，m6A 修饰的复杂调控网络涉及多个 m6A 相关调控蛋白，其生物学功能已得到进一步分析。
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