Acetylcholine modulates K+ and Na+ currents in human basal forebrain cholinergic neuroblasts through an autocrine/paracrine mechanism,Journal of Neurochemistry

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Acetylcholine modulates K+ and Na+ currents in human basal forebrain cholinergic neuroblasts through an autocrine/paracrine mechanism
Journal of Neurochemistry ( IF 4.2 ) Pub Date : 2020-10-08 , DOI: 10.1111/jnc.15209
Elisabetta Coppi ₁ , Federica Cherchi ₁ , Erica Sarchielli ₂ , Irene Fusco ₁ , Giulia Guarnieri ₂ , Pasquale Gallina ₁ , Renato Corradetti ₁ , Felicita Pedata ₁ , Gabriella B Vannelli ₂ , Anna Maria Pugliese ₁ , Annamaria Morelli ₂

Affiliation

The Nucleus Basalis of Meynert (NBM) is the main source of cholinergic neurons in the basal forebrain to be crucially involved in cognitive functions and whose degeneration correlates with cognitive decline in major degenerative pathologies as Alzheimer's and Parkinson's diseases. However, knowledge concerning NBM neurons derived from human brain is very limited to date.

中文翻译：

乙酰胆碱通过自分泌/旁分泌机制调节人基础前脑胆碱能神经母细胞中的K +和Na +电流

Meynert的基础基底核（NBM）是基底前脑中胆碱能神经元的主要来源，其至关重要地参与了认知功能，并且其退化与主要退化性疾病（如阿尔茨海默氏病和帕金森氏病）的认知能力下降有关。但是，迄今为止，有关源自人脑的NBM神经元的知识非常有限。

更新日期：2020-10-08

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