Kinetics and isotype assessment of antibodies targeting the spike protein receptor‐binding domain of severe acute respiratory syndrome‐coronavirus‐2 in COVID‐19 patients as a function of age, biological sex and disease severity,Clinical & Translational Immunology

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Kinetics and isotype assessment of antibodies targeting the spike protein receptor‐binding domain of severe acute respiratory syndrome‐coronavirus‐2 in COVID‐19 patients as a function of age, biological sex and disease severity
Clinical & Translational Immunology ( IF 4.6 ) Pub Date : 2020-10-07 , DOI: 10.1002/cti2.1189
Nancy R Graham _{1,

2} , Annalis N Whitaker _{3,

4,

5} , Camilla A Strother _{1,

4} , Ashley K Miles _{1,

2} , Dore Grier ₆ , Benjamin D McElvany _{1,

2} , Emily A Bruce _{3,

5,

7} , Matthew E Poynter _{4,

5,

7,

8,

9} , Kristen K Pierce _{1,

2,

7,

10} , Beth D Kirkpatrick _{1,

2,

5,

7,

10} , Renee D Stapleton _{8,

9} , Gary An _{7,

11} , Eline van den Broek-Altenburg ₁₂ , Jason W Botten _{1,

2,

3,

4,

5,

7} , Jessica W Crothers _{5,

7,

10} , Sean A Diehl _{1,

2,

4,

5,

7}

Affiliation

Department of Microbiology and Molecular Genetics Larner College of Medicine, University of Vermont Burlington VT USA.
Vaccine Testing Center Larner College of Medicine, University of Vermont Burlington VT USA.
Department of Medicine-Immunobiology Larner College of Medicine, University of Vermont Burlington VT USA.
Cellular, Molecular, and Biomedical Sciences Graduate Program University of Vermont Burlington VT USA.
Vermont Center for Immunology and Infectious Disease Larner College of Medicine, University of Vermont Burlington VT USA.
Department of Pathology and Laboratory Medicine Larner College of Medicine, University of Vermont Burlington VT USA.
Translational Global Infectious Disease Research Center University of Vermont Burlington VT USA.
Vermont Lung Center Larner College of Medicine, University of Vermont Burlington VT USA.
Department of Medicine-Pulmonary and Critical Care Larner College of Medicine, University of Vermont Burlington VT USA.
Department of Medicine-Infectious Disease Larner College of Medicine University of Vermont Burlington VT USA.
Department of Surgery Larner College of Medicine, University of Vermont Burlington VT USA.
Department of Radiology Larner College of Medicine, University of Vermont Burlington VT USA.

There is an incomplete understanding of the host humoral immune response to severe acute respiratory syndrome (SARS)‐coronavirus (CoV)‐2, which underlies COVID‐19, during acute infection. Host factors such as age and sex as well as the kinetics and functionality of antibody responses are important factors to consider as vaccine development proceeds. The receptor‐binding domain of the CoV spike (RBD‐S) protein mediates host cell binding and infection and is a major target for vaccine design to elicit neutralising antibodies.

中文翻译：

COVID-19患者中针对严重急性呼吸综合征-冠状病毒-2刺突蛋白受体结合域的抗体的动力学和同种型评估与年龄、生物性别和疾病严重程度的关系

对于急性感染期间宿主对严重急性呼吸综合征 (SARS)-冠状病毒 (CoV)-2 的体液免疫反应尚不完全了解，严重急性呼吸综合征 (SARS)-冠状病毒 (CoV)-2 是 COVID-19 的基础。年龄和性别等宿主因素以及抗体反应的动力学和功能是疫苗开发过程中需要考虑的重要因素。冠状病毒刺突 (RBD-S) 蛋白的受体结合域介导宿主细胞结合和感染，是疫苗设计引发中和抗体的主要目标。

更新日期：2020-10-08

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