The multifaceted role of cell cycle regulators in the coordination of growth and metabolism,The FEBS Journal

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The multifaceted role of cell cycle regulators in the coordination of growth and metabolism
The FEBS Journal ( IF 5.5 ) Pub Date : 2020-10-08 , DOI: 10.1111/febs.15586
Katharina Huber ₁ , Alberto Mestres-Arenas ₁ , Lluis Fajas ₁ , Lucia C Leal-Esteban ₁

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Adapting to changes in nutrient availability and environmental conditions is a fundamental property of cells. This adaptation requires a multi-directional coordination between metabolism, growth, and the cell cycle regulators (consisting of the family of cyclin-dependent kinases (CDKs), their regulatory subunits known as cyclins, CDK inhibitors, the retinoblastoma family members, and the E2F transcription factors). Deciphering the mechanisms accountable for this coordination is crucial for understanding various patho-physiological processes. While it is well established that metabolism and growth affect cell division, this review will focus on recent observations that demonstrate how cell cycle regulators coordinate metabolism, cell cycle progression, and growth. We will discuss how the cell cycle regulators directly regulate metabolic enzymes and pathways and summarize their involvement in the endolysosomal pathway and in the functions and dynamics of mitochondria.

中文翻译：

细胞周期调节剂在生长和代谢协调中的多方面作用

适应营养供应和环境条件的变化是细胞的基本特性。这种适应需要代谢、生长和细胞周期调节因子（由细胞周期蛋白依赖性激酶 (CDK) 家族及其称为细胞周期蛋白、CDK 抑制剂、视网膜母细胞瘤家族成员和 E2F 的调节亚基）之间的多向协调转录因子）。破译负责这种协调的机制对于理解各种病理生理过程至关重要。虽然代谢和生长会影响细胞分裂已是公认的事实，但本综述将重点关注最近的观察结果，这些观察结果展示了细胞周期调节剂如何协调代谢、细胞周期进程和生长。

更新日期：2020-10-08

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