Rapid nuclear magnetic resonance data acquisition with improved resolution and sensitivity for high‐throughput metabolomic analysis,Magnetic Resonance in Chemistry

当前位置： X-MOL 学术 › Magn. Reson. Chem. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Rapid nuclear magnetic resonance data acquisition with improved resolution and sensitivity for high‐throughput metabolomic analysis
Magnetic Resonance in Chemistry ( IF 1.9 ) Pub Date : 2020-11-02 , DOI: 10.1002/mrc.5106
David Joseph ₁ , Sujeesh Sukumaran ₁ , Kousik Chandra ₁ , Shivanand M Pudakalakatti ₁ , Abhinav Dubey ₁ , Amrinder Singh ₁ , Hanudatta S Atreya ₁

Affiliation

NMR-based metabolomics has witnessed rapid advancements in recent years with the continuous development of new methods to enhance the sensitivity, resolution and speed of data acquisition. Some of the approaches were earlier used for peptide and protein resonance assignments and have now been adapted to metabolomics. At the same time, new NMR methods involving novel data acquisition techniques, suited particularly for high-throughput analysis in metabolomics, have been developed. In this review, we focus on the different sampling strategies or data acquisition methods that have been developed in our laboratory and other groups to acquire NMR spectra rapidly with high sensitivity and resolution for metabolomics. In particular, we focus on the use of multiple receivers, phase modulation NMR spectroscopy and fast pulsing methods for identification and assignments of metabolites.

中文翻译：

具有更高分辨率和灵敏度的快速核磁共振数据采集，用于高通量代谢组学分析

近年来，随着新方法的不断发展，以 NMR 为基础的代谢组学取得了快速发展，以提高数据采集的灵敏度、分辨率和速度。一些方法早先用于肽和蛋白质共振分配，现在已适用于代谢组学。同时，已经开发了涉及新数据采集技术的新 NMR 方法，特别适用于代谢组学中的高通量分析。在这篇综述中，我们重点介绍了我们实验室和其他小组开发的不同采样策略或数据采集方法，以快速获取代谢组学的高灵敏度和分辨率的 NMR 谱。特别是，我们专注于使用多个接收器，

更新日期：2020-11-02

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11