The aim of this study was to evaluate the hypoglycemic and antioxidant potential of konjac in vitro and in vivo. Glucose diffusion and enzymatic starch digestion of konjac were assayed using α‐amylase and α‐glucosidase. Oral glucose tolerance test (OGTT) and oral starch tolerance test (OSTT) were performed at dose of 102 mg/Kg of body weight (equivalent to 1 g/meal in humans). Additionally, the antioxidant activity of konjac was evaluated through inhibition of lipid peroxidation. The konjac decreased glucose diffusion by 36% and 19% compared with the negative and positive controls, respectively. Additionally, konjac inhibited α‐amylase and α‐glucosidase activities by 14% and 90%, respectively. After OSTT, group treated with konjac showed significant lower glucose levels compared with control group (p = .03). Finally, konjac reduced lipid peroxidation in human plasma (93%) compared with the negative control. Our results suggest that konjac exhibits hypoglycemic and antioxidant activities in vitro and in vivo.

中文翻译：

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魔芋（Amorphophallus konjac）体内外的降血糖和抗氧化特性

这项研究的目的是评估魔芋在体外和体内的降血糖和抗氧化潜力。用α-淀粉酶和α-葡萄糖苷酶测定魔芋的葡萄糖扩散和酶促淀粉消化率。口服葡萄糖耐量测试（OGTT）和口服淀粉耐量测试（OSTT）的剂量为102 mg / Kg体重（相当于人中1 g /餐）。另外，通过抑制脂质过氧化来评价魔芋的抗氧化活性。与阴性对照和阳性对照相比，魔芋的葡萄糖扩散分别降低了36％和19％。此外，魔芋分别抑制α-淀粉酶和α-葡萄糖苷酶活性14％和90％。OSTT后，魔芋治疗组的血糖水平明显低于对照组（p = .03）。最后，魔芋与阴性对照相比降低了人血浆中的脂质过氧化作用（93％）。我们的结果表明魔芋在体外和体内均表现出降血糖和抗氧化活性。