Chemical warfare (CW) exposure could be fatal to military and civilians through skin contamination. Our work and others focus on investigating stratum corneum reservoir with less regards to skin appendageal routes including hair follicles. Here, C‐14 CW simulants (CWS) with specific activity of 0.1 mCi/ml were tested on abdominal and scalp human cadaver skin using flow‐through diffusion system. Quantitative analysis of simulants in skin compartments were performed using scintillation counter. Scalp permeation of dipropylene glycol monomethyl ether (DPGME), diisopropyl methylphosphonate (DIMP) and methyl salicylate (MeS) exceed abdominal skin by 8%, 15%, and 6% (p value < 0.05) of applied dose, respectively. DPGME and DIMP (most hydrophilic) showed earlier permeation peak time (Tmax) through scalp skin at 2 and 4 h, respectively, comparing with 6 h with abdominal skin. The percentage of applied dose of DPGME and DIMP retained in human skin membrane (SC, epidermis, and viable dermis) showed no statistically significant difference between tested abdominal and scalp skin samples (p value >0.05). The percentage of applied dose of MeS in scalp showed higher partitioning in stratum corneum and viable epidermis than abdominal skin (p value <0.05).

中文翻译：

---

毛囊通路在化学战模拟物经皮渗透中的作用

化学战 (CW) 暴露可能会通过皮肤污染对军人和平民造成致命伤害。我们和其他人的工作重点是调查角质层储库，而较少关注包括毛囊在内的皮肤附属路径。在这里，使用流通扩散系统在腹部和头皮人体尸体皮肤上测试了比活性为 0.1 mCi/ml 的 C-14 CW 模拟物（CWS）。使用闪烁计数器对皮肤隔室中的模拟物进行定量分析。二丙二醇单甲醚 (DPGME)、甲基膦酸二异丙酯 (DIMP) 和水杨酸甲酯 (MeS) 的头皮渗透率超过腹部皮肤 8%、15% 和 6%（p值 < 0.05) 的应用剂量，分别。DPGME 和 DIMP（最亲水的）分别在 2 小时和 4 小时显示出更早的通过头皮皮肤的渗透峰值时间 (Tmax)，而腹部皮肤则为 6 小时。保留在人皮肤膜（SC、表皮和活真皮）中的 DPGME 和 DIMP 的应用剂量百分比显示，测试的腹部和头皮皮肤样品之间没有统计学显着差异（p值 >0.05）。头皮中 MeS 的应用剂量百分比显示，角质层和活表皮中的分配比腹部皮肤更高（p值 <0.05）。