The neural basis for mental state attribution: A voxel‐based lesion mapping study,Human Brain Mapping

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The neural basis for mental state attribution: A voxel‐based lesion mapping study
Human Brain Mapping ( IF 3.5 ) Pub Date : 2020-10-08 , DOI: 10.1002/hbm.25203
Shira Cohen-Zimerman _{1,

2} , Harsh Khilwani _{1,

3} , Gretchen N L Smith ₁ , Frank Krueger _{4,

5} , Barry Gordon _{6,

7} , Jordan Grafman _{1,

2,

8}

Affiliation

The ability to infer other persons' mental states, “Theory of Mind” (ToM), is a key function of social cognition and is needed when interpreting the intention of others. ToM is associated with a network of functionally related regions, with reportedly key prominent hubs located in the dorsolateral prefrontal cortex (dlPFC) and the temporoparietal junction (TPJ). The involvement of (mainly the right) TPJ in ToM is based primarily on functional imaging studies that provide correlational evidence for brain‐behavior associations. In this lesion study, we test whether certain brain areas are necessary for intact ToM performance. We investigated individuals with penetrating traumatic brain injury (n = 170) and healthy matched controls (n = 30) using voxel‐based lesion‐symptom mapping (VLSM) and by measuring the impact of a given lesion on white matter disconnections. ToM performance was compared between five patient groups based on lesion location: right TPJ, left TPJ, right dlPFC, left dlPFC, and other lesion, as well as healthy controls. The only group to present with lower ToM abilities was the one with lesions in the right dlPFC. Similarly, VLSM analysis revealed a main cluster in the right frontal middle gyrus and a secondary cluster in the left inferior parietal gyrus. Last, we found that disconnection of the left inferior longitudinal fasciculus and right superior longitudinal fasciculus were associated with poor ToM performance. This study highlights the importance of lesion studies in complementing functional neuroimaging findings and supports the assertion that the right dlPFC is a key region mediating mental state attribution.

中文翻译：

精神状态归因的神经基础：基于体素的病变映射研究

推断他人心理状态的能力，即“心理理论”(ToM)，是社会认知的关键功能，是解释他人意图时所需要的。 ToM 与功能相关区域网络相关，据报道关键的突出中枢位于背外侧前额叶皮层 (dlPFC) 和颞顶交界处 (TPJ)。 ToM 中（主要是右侧）TPJ 的参与主要基于功能成像研究，该研究为大脑行为关联提供了相关证据。在这项损伤研究中，我们测试了某些大脑区域对于完整的 ToM 表现是否是必需的。我们使用基于体素的病变症状图谱 (VLSM) 并通过测量给定病变对白质断开的影响，对患有穿透性脑外伤的个体 ( n = 170) 和健康匹配对照 ( n = 30) 进行了研究。根据病变位置比较五个患者组的 ToM 表现：右 TPJ、左 TPJ、右 dlPFC、左 dlPFC 和其他病变以及健康对照。唯一表现出 ToM 能力较低的一组是右侧 dlPFC 损伤的一组。同样，VLSM 分析显示右侧额中回有一个主要簇，左侧顶下回有一个次要簇。最后，我们发现左下纵束和右上纵束的断开与 ToM 表现不佳相关。这项研究强调了病变研究在补充功能性神经影像学发现方面的重要性，并支持右 dlPFC 是介导精神状态归因的关键区域的主张。

更新日期：2020-12-08

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