Sudden blast phase in pediatric chronic myeloid leukemia-chronic phase with abnormal lymphoid blasts detected by flow cytometry at diagnosis: Can it be considered a warning sign?,Cytometry Part B: Clinical Cytometry

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Sudden blast phase in pediatric chronic myeloid leukemia-chronic phase with abnormal lymphoid blasts detected by flow cytometry at diagnosis: Can it be considered a warning sign?
Cytometry Part B: Clinical Cytometry ( IF 3.4 ) Pub Date : 2020-10-08 , DOI: 10.1002/cyto.b.21958
Kalasekhar Vijayasekharan _{1,

2,

3} , Gaurav Chatterjee _{2,

4} , Subramaniam Ramanathan _{1,

2} , Gaurav Narula _{1,

2} , Prashant Tembhare _{2,

4} , Papagudi G Subramanian _{2,

4} , Nikhil Patkar _{2,

4} , Sumeet Gujral _{2,

4} , Dhanlaxmi Shetty _{2,

4} , Shripad Banavali _{1,

2}

Affiliation

Inconclusive knowledge persists regarding the course of chronic myeloid leukemia-chronic phase (CML-CP) patients with detectable abnormal blasts by flow-cytometry at diagnosis. The 2016 WHO classification is not specific regarding sub-classification of CML with <10% abnormal B-lymphoid blasts (ABLB), and suggests these patients often show rapid progression. We report the clinical course of pediatric CML-CP patients who had detectable abnormal blasts by flow-cytometry at baseline.

中文翻译：

小儿慢性粒细胞白血病的急变期——诊断时流式细胞仪检测到异常淋巴母细胞的慢性期：它可以被认为是一个警告信号吗？

关于慢性粒细胞白血病 - 慢性期 (CML-CP) 患者在诊断时通过流式细胞术可检测到异常原始细胞的病程仍然存在不确定的知识。2016 年的 WHO 分类对于 CML 的亚分类没有具体说明，异常 B 淋巴母细胞 (ABLB) <10%，并表明这些患者通常表现出快速进展。我们报告了在基线时通过流式细胞术检测到异常原始细胞的儿科 CML-CP 患者的临床过程。

更新日期：2020-10-08

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