The basic helix-loop-helix transcription factor (TF) Bhlhe40 is emerging as a key regulator of immunity during infection, autoimmunity, and inflammatory conditions. We describe the roles of Bhlhe40 in the circulating and tissue-resident arms of the immune system, with emphasis on recent work on the regulation of cytokine production and proliferation. We explore the mechanisms behind these functions in mouse models and human cells, including interactions with other TFs, and propose that Bhlhe40 is a central mediator of both inflammation and pathogen control, as well as a crucial regulator of a growing number of tissue-resident leukocyte populations. Finally, we suggest areas for further study that may advance our understanding of immunity and disease.

基本的螺旋-环-螺旋转录因子 (TF) Bhlhe40 正在成为感染、自身免疫和炎症期间免疫的关键调节剂。我们描述了 Bhlhe40 在免疫系统的循环和组织驻留臂中的作用，重点是最近在调节细胞因子产生和增殖方面的工作。我们探索了小鼠模型和人类细胞中这些功能背后的机制，包括与其他 TF 的相互作用，并提出 Bhlhe40 是炎症和病原体控制的中心介质，也是越来越多的组织驻留白细胞的关键调节剂人口。最后，我们建议进一步研究的领域，以促进我们对免疫和疾病的理解。