The emergence of antifungal resistance is a serious threat in the treatment of mycoses. The primary susceptible fungal cells may evolve a resistance after longer exposure to antifungal agents. The exposure itself causes stress condition, to which the fungus needs to adapt. This review provides detailed description of evolutionary conserved molecular mechanisms contributing to the adaptation response to stress caused by antifungal agents as well as their interconnection. The knowledge may help us to find new ways to delay the emergence of drug resistance as the same mechanisms are used regardless of what antifungal compound causes stress.

中文翻译：

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参与抗真菌药物应激反应的信号机制

抗真菌耐药性的出现是真菌病治疗的严重威胁。初级易感真菌细胞在长期接触抗真菌剂后可能会产生抗药性。暴露本身会导致压力状况，真菌需要适应这种状况。这篇综述详细描述了进化保守分子机制，这些机制有助于对抗真菌剂引起的应激的适应反应以及它们的相互联系。这些知识可以帮助我们找到新的方法来延迟耐药性的出现，因为无论哪种抗真菌化合物会引起压力，都使用相同的机制。