Osteolysis is characterized by the imbalance of bone remodeling triggered by excessive activation of osteoclasts, which ultimately leads to pathological bone destruction. Diseases caused by overactive osteoclasts, such as osteolysis around the prosthesis, periodontitis and osteoporosis, are clinically common but lack effective treatment. Therefore, exploring regimens that could specifically impair the formation and function of osteoclasts has become a breakthrough in the treatment of these diseases. Carnosol is a natural phenolic diterpene with anti-inflammatory, antibacterial, anti-tumor and antioxidant properties. In this study, we found that carnosol can impede RANKL-induced osteoclastogenesis via modulating the activation of NF-κb and JNK signaling pathways in vitro. Additionally, we confirmed that carnosol could alleviate bone loss in a murine model of LPS-induced inflammatory bone erosion in vivo. Thence, these findings demonstrate that carnosol may be a potentially effective regent for the treatment of osteoclast-related disorders.

溶骨的特点是破骨细胞过度活化引发的骨骼重塑失衡，最终导致病理性骨破坏。由破骨细胞过度活跃引起的疾病，例如假体周围的骨溶解，牙周炎和骨质疏松症，在临床上很普遍，但缺乏有效的治疗方法。因此，探索可能特别破坏破骨细胞形成和功能的疗法已成为治疗这些疾病的突破。卡诺索尔是一种天然的酚二萜，具有抗炎，抗菌，抗肿瘤和抗氧化的特性。在这项研究中，我们发现鼠尾草酚可以通过调节体外NF-κb和JNK信号通路的激活来阻止RANKL诱导的破骨细胞生成。另外，我们证实，鼠尾草酚可以减轻LPS引起的小鼠体内炎症性骨侵蚀的小鼠模型中的骨质流失。因此，这些发现表明，鼠尾草酚可能是治疗破骨细胞相关疾病的潜在有效方法。