Convenient structures such as 2,4-diketo esters have been widely used as an effective pattern in medicinal chemistry and pharmacology for drug discovery. 2,4-Diketonate is a common scaffold that can be found in many biologically active and naturally occurring compounds. Also, many 2,4-diketo ester derivatives have been prepared due to their suitable synthesis. These synthetic drugs and natural products have shown numerous interesting biological properties with clinical potential as a cure for the broad specter of diseases. This review aims to highlight the important evidence of 2,4-diketo esters as a privileged scaffold in medicinal chemistry and pharmacology. Herein, numerous aspects of 2,4-diketo esters will be summarized, including synthesis and isolation of their derivatives, development of novel synthetic methodologies, the evaluation of their biological properties as well as the mechanisms of action of the diketo ester derivates. This paperwork is expected to be a comprehensive, trustworthy, and critical review of the 2,4-diketo ester intermediate to the chemistry community.

方便的结构，例如2，4-二酮酯已广泛用作药物化学和药理学中发现药物的有效方式。2,4-二酮酸酯是一种常见的支架，可以在许多具有生物活性和天然存在的化合物中找到。同样，由于它们合适的合成，已经制备了许多2，4-二酮酯衍生物。这些合成药物和天然产物显示出许多有趣的生物学特性，具有临床潜力，可治愈多种疾病。这篇综述旨在突出2,4-二酮酸酯作为药物化学和药理学中的一种特殊支架的重要证据。在此，将概述2，4-二酮酯的各个方面，包括其衍生物的合成和分离，新型合成方法的开发，评估其生物学特性以及二酮酯衍生物的作用机理。预期本文工作将是化学界对2,4-二酮酯中间体的全面，可信赖且严格的评论。