Amyris is a fermentation product company that leverages synthetic biology and has been bringing novel fermentation products to the market since 2009. Driven by breakthroughs in genome editing, strain construction and testing, analytics, automation, data science, and process development, Amyris has commercialized nine separate fermentation products over the last decade. This has been accomplished by partnering with the teams at 17 different manufacturing sites around the world. This paper begins with the technology that drives Amyris, describes some key lessons learned from early scale-up experiences, and summarizes the technology transfer procedures and systems that have been built to enable moving more products to market faster. Finally, the breadth of the Amyris product portfolio continues to expand; thus the steps being taken to overcome current challenges (e.g. automated strain engineering can now outpace the rest of the product commercialization timeline) are described.

Amyris是一家利用合成生物学技术生产发酵产品的公司，自2009年以来一直将新颖的发酵产品推向市场。在基因组编辑，菌株构建和测试，分析，自动化，数据科学和工艺开发方面取得突破，Amyris已将9种产品商业化在过去十年中分离出发酵产品。这是通过与全球17个不同制造厂的团队合作完成的。本文从驱动Amyris的技术入手，描述了从早期扩展经验中学到的一些重要经验教训，并总结了为使更多产品更快地推向市场而构建的技术转让程序和系统。最终，Amyris产品组合的范围不断扩大；