Significance: Our study is the first comparison of brain activation patterns during motor tasks across unilateral cerebral palsy (UCP), bilateral cerebral palsy (BCP), and typical development (TD) to elucidate neural mechanisms and inform rehabilitation strategies. Aim: Cortical activation patterns were compared for distal upper and lower extremity tasks in UCP, BCP, and TD using functional near-infrared spectroscopy (fNIRS) and related to functional severity. Approach: Individuals with UCP (n = 10, 18.8 ± 6.8 years), BCP (n = 14, 17.5 ± 9.6 years), and TD (n = 16, 17.3 ± 9.1 years) participated in this cross-sectional cohort study. The fNIRS was used to noninvasively monitor the hemodynamic response to task-related cortical activation. The block design involved repetitive nondominant hand squeezing and ankle dorsiflexion. Results: Individuals with UCP demonstrated the highest levels of activation for the squeeze task (UCP > BCP q = 0.049; BCP > TD q < 0.001; and UCP > TD q = 0.001) and more activity in the ipsilateral versus contralateral hemisphere. Individuals with BCP showed the highest levels of cortical activation in the dorsiflexion task (BCP > UCP q < 0.001; BCP > TD). Conclusions: Grouping by CP subtype and manual function or mobility level demonstrated significant differences from TD, even for individuals with the mildest forms of CP. Hemispheric activation patterns showed hypothesized but nonsignificant trends.

中文翻译：

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功能性近红外光谱用于评估患有或不患有双侧和单侧脑瘫的个体在手挤压和踝背屈期间的感觉运动皮层活动


意义：我们的研究首次比较了单侧脑瘫（UCP）、双侧脑瘫（BCP）和典型发育（TD）运动任务期间的大脑激活模式，以阐明神经机制并为康复策略提供信息。目的：使用功能性近红外光谱 (fNIRS) 比较 UCP、BCP 和 TD 中远端上肢和下肢任务的皮质激活模式，并与功能严重程度相关。方法：UCP（n = 10，18.8 ± 6.8 岁）、BCP（n = 14，17.5 ± 9.6 岁）和 TD（n = 16，17.3 ± 9.1 岁）个体参与了这项横断面队列研究。 fNIRS 用于无创监测对任务相关皮质激活的血流动力学反应。块设计涉及重复的非惯用手挤压和脚踝背屈。结果：患有 UCP 的个体表现出最高水平的挤压任务激活水平（UCP > BCP q = 0.049；BCP > TD q < 0.001；和 UCP > TD q = 0.001），并且同侧与对侧相比活动更多半球。患有 BCP 的个体在背屈任务中表现出最高水平的皮质激活（BCP > UCP q < 0.001；BCP > TD）。结论：按 CP 亚型和手动功能或活动水平进行分组显示与 TD 存在显着差异，即使对于患有最轻度 CP 的个体也是如此。半球激活模式显示出假设但不显着的趋势。