During our synthetic development work focused on new Bcl-2 inhibitor molecules an unexpected and interesting by-product was formed. Using this obsevation we have explored the synthesis of the hitherto unknown pyrrolo[2,3]pyrido[2,4-d]pyrimidin-6-one heterocyclic core. The study of the scope and limitations of this cyclisation resulted in other three new types of three membered heterocyclic ring systems.

中文翻译：

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吡咯并[2,3]吡啶[2,4-]的合成

在我们针对新的Bcl-2抑制剂分子的合成开发工作中，形成了意想不到的有趣副产物。利用这种观察，我们探索了迄今未知的吡咯并[2,3]吡啶基[2,4 - d ]嘧啶-6-杂环的合成。对这种环化的范围和局限性的研究导致了其他三种新型的三元杂环系统。