Body temperature polymerization and in situ drug encapsulation in supercritical carbon dioxide,Polymer Chemistry

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Body temperature polymerization and in situ drug encapsulation in supercritical carbon dioxide
Polymer Chemistry ( IF 4.1 ) Pub Date : 2020-10-07 , DOI: 10.1039/d0py01131b
Zi-Kun Rao _{1,

2,

3,

4} , Tian-Qiang Wang _{4,

5,

6,

7} , Yang Li _{1,

2,

3,

4} , Hong-Yu Zhu _{1,

2,

3,

4} , Yu Liu _{1,

2,

3,

4} , Jian-Yuan Hao _{1,

2,

3,

4}

Affiliation

Body-temperature and solvent-free polymerization and in situ fabrication of drug-loaded microparticles are reported for the first time. The key point is to simplify the cumbersome processes and avoid the harsh conditions in the traditional fabrication of biodegradable medical microparticles, reducing the energy consumption and fabricating cleaner biodegradable formulations with controlled size and drug release profiles. We have designed a surfactant P(CL–GA)–PFPE–P(CL–GA) which efficiently promotes the formation of narrowly distributed microparticles of minimum 5 μm at body temperature. The following drug loading investigation confirmed that PTX evenly distributes in the PPDO microparticles in amorphous state, giving a controlled release profile with the cumulative releasing rate reaching 50% in one month. Most importantly, all the processes are conducted at body temperature in one-pot, presenting promising possibilities of both energy and cost conservation.

中文翻译：

超临界二氧化碳中的体温聚合和原位药物封装

体温和无溶剂原位聚合首次报道了载药微粒的制备。关键是简化繁琐的过程，避免传统的可生物降解医用微粒制造过程中的苛刻条件，减少能耗并制造尺寸和药物释放曲线可控的更清洁的可生物降解制剂。我们设计了一种表面活性剂P（CL-GA）-PFPE-P（CL-GA），可有效促进体温下最小5μm的窄分布微粒的形成。随后的载药量研究证实，PTX在无定形状态下均匀分布在PPDO微粒中，具有控释特性，累积释放率在一个月内达到50％。最重要的是，所有过程都在一个锅中于体温下进行，

更新日期：2020-11-03

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