Structural perspective on revealing heat dissipation behavior of CoFe2O4–Pd nanohybrids: great promise for magnetic fluid hyperthermia,Physical Chemistry Chemical Physics

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Structural perspective on revealing heat dissipation behavior of CoFe2O4–Pd nanohybrids: great promise for magnetic fluid hyperthermia
Physical Chemistry Chemical Physics ( IF 2.9 ) Pub Date : 2020-10-07 , DOI: 10.1039/d0cp02076a
S. Fatemeh Shams _{1,

2,

3,

4} , Mohammad Reza Ghazanfari _{4,

5,

6,

7} , Susanne Pettinger _{4,

8,

9,

10,

11} , Amir H. Tavabi _{2,

3,

4,

12} , Konrad Siemensmeyer _{4,

13,

14} , Alevtina Smekhova _{1,

2,

3,

4} , Rafal E. Dunin-Borkowski _{2,

3,

4,

12} , Gil G. Westmeyer _{4,

8,

9,

10,

11} , Carolin Schmitz-Antoniak _{1,

2,

3,

4}

Affiliation

Loss mechanisms in fluid heating of cobalt ferrite (CFO) nanoparticles and CFO–Pd heterodimer colloidal suspensions are investigated as a function of particle size, fluid concentration and magnetic field amplitude. The specific absorption rate (SAR) is found to vary with increasing particle size due to a change in dominant heating mechanism from susceptibility to hysteresis and frictional loss. The maximum SAR is obtained for particle diameters of 11–15 nm as a result of synergistic contributions of susceptibility loss, including Néel and Brownian relaxation and especially hysteresis loss, thereby validating the applicability of linear response theory to superparamagnetic CFO nanoparticles. Our results show that the ferrofluid concentration and magnetic field amplitude alter interparticle interactions and associated heating efficiency. The SAR of the CFO nanoparticles could be maximized by adjusting the synthesis parameters. Despite the paramagnetic properties of individual palladium nanoparticles, CFO–Pd heterodimer suspensions were observed to have surprisingly improved magnetization as well as SAR values, when compared with CFO ferrofluids. This difference is attributed to interfacial interactions between the magnetic moments of paramagnetic Pd and superparamagnetic/ferrimagnetic CFO. SAR values measured from CFO–Pd heterodimer suspensions were found to be 47–52 W g_Ferrite⁻¹, which is up to a factor of two higher than the SAR values of commercially available ferrofluids, demonstrating their potential as efficient heat mediators. Our results provide insight into the utilization of CFO–Pd heterodimer suspensions as potential nanoplatforms for diagnostic and therapeutic biomedical applications, e.g., in cancer hyperthermia, cryopreserved tissue warming, thermoablative therapy, drug delivery and bioimaging.

中文翻译：

揭示CoFe2O4-Pd纳米杂化物散热行为的结构透视：磁流体热疗的广阔前景

研究了钴铁氧体（CFO）纳米颗粒和CFO-Pd异二聚体胶体悬浮液在流体加热中的损失机理，该机理与粒径，流体浓度和磁场振幅有关。发现由于主要的加热机理从磁化率到磁滞和摩擦损失的变化，比吸收率（SAR）随粒径的增加而变化。由于磁化率损失（包括Néel和Brownian弛豫，尤其是磁滞损失）的协同作用，获得了针对11-15 nm粒径的最大SAR，从而验证了线性响应理论对超顺磁性CFO纳米粒子的适用性。我们的结果表明，铁磁流体浓度和磁场振幅会改变颗粒间的相互作用以及相关的加热效率。可以通过调整合成参数来最大化CFO纳米粒子的SAR。尽管单个钯纳米粒子具有顺磁性，但与CFO铁磁流体相比，CFO–Pd异二聚体悬浮液的磁化强度和SAR值却得到了惊人的改善。这种差异归因于顺磁性Pd和超顺磁性/亚铁磁性CFO的磁矩之间的界面相互作用。从CFO–Pd异二聚体悬浮液测得的SAR值为47–52 W g 这种差异归因于顺磁性Pd和超顺磁性/亚铁磁性CFO的磁矩之间的界面相互作用。从CFO–Pd异二聚体悬浮液测得的SAR值为47–52 W g 这种差异归因于顺磁性Pd和超顺磁性/亚铁磁性CFO的磁矩之间的界面相互作用。从CFO–Pd异二聚体悬浮液测得的SAR值为47–52 W g_铁氧体^-1最高比市售铁磁流体的SAR值高2倍，证明了其作为高效热介质的潜力。我们的结果提供了对CFO-Pd异二聚体悬浮液作为潜在纳米平台用于诊断和治疗生物医学应用（例如在癌症热疗，冷冻保存的组织升温，热消融治疗，药物递送和生物成像中的潜在纳米平台）的见解。

更新日期：2020-10-20

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