Background Peripheral artery disease (PAD) can be an important predictor of comorbid cerebrovascular disease (CVD). However, it is not sufficiently investigated or considered in the management and prevention of stroke. Objectives To study the prevalence of peripheral arterial disease in large artery ischemic stroke patients and its impact on prognosis. Methods This is a prospective cohort study. A total of 100 patients with large artery ischemic stroke were enrolled with assessment for signs of PAD; duplex on both lower limb arteries and measurement of ankle-brachial index (ABI), carotid duplex, and/or C.T angiography brain and neck and/or conventional angiography; functional assessment by NIHSS at days 0, 7, and 30; and follow-up for recurrence or death after 6 months. Results Peripheral arterial disease was found in 42% of cases. Fifty percent of patients with lower extremity arterial disease were asymptomatic. Fifty percent had significant carotid stenosis (stenosis > 50%), and 48% of patients with significant carotid stenosis had peripheral arterial disease. During our study, 8 cases had a recurrence of large artery ischemic stroke, and 5 cases (62.5%) had PAD. The recurrence rate of stroke was the highest in the asymptomatic PAD group with 19%. Conclusion The prevalence of PAD in large artery ischemic stroke patients is high. Asymptomatic PAD has a risk potential for large artery ischemic stroke recurrence and mortality more than symptomatic PAD and non-PAD patients.

中文翻译：

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大动脉缺血性卒中患者外周动脉疾病患病率及预后价值

背景 外周动脉疾病 (PAD) 可能是合并脑血管疾病 (CVD) 的重要预测因素。然而，在卒中的管理和预防中并未对其进行充分研究或考虑。目的研究大动脉缺血性脑卒中患者外周动脉疾病的患病率及其对预后的影响。方法 这是一项前瞻性队列研究。共招募了 100 名大动脉缺血性卒中患者，以评估 PAD 的体征；双下肢动脉和踝臂指数 (ABI)、颈动脉双工和/或 CT 血管造影脑和颈部和/或常规血管造影的测量；NIHSS 在第 0、7 和 30 天进行的功能评估；6个月后随访复发或死亡。结果 42%的病例发现外周动脉疾病。50% 的下肢动脉疾病患者没有症状。50% 有显着颈动脉狭窄（狭窄 > 50%），48% 有显着颈动脉狭窄的患者有外周动脉疾病。在我们的研究中，8 例大动脉缺血性卒中复发，5 例（62.5%）有 PAD。无症状 PAD 组的卒中复发率最高，为 19%。结论大动脉缺血性脑卒中患者PAD患病率较高。与有症状的 PAD 和非 PAD 患者相比，无症状的 PAD 具有更大的大动脉缺血性卒中复发和死亡的潜在风险。48% 的颈动脉明显狭窄患者有外周动脉疾病。在我们的研究中，8 例大动脉缺血性卒中复发，5 例（62.5%）有 PAD。无症状 PAD 组的卒中复发率最高，为 19%。结论大动脉缺血性脑卒中患者PAD患病率较高。与有症状的 PAD 和非 PAD 患者相比，无症状的 PAD 具有更大的大动脉缺血性卒中复发和死亡的潜在风险。48% 的颈动脉明显狭窄患者有外周动脉疾病。在我们的研究中，8 例大动脉缺血性卒中复发，5 例（62.5%）有 PAD。无症状 PAD 组的卒中复发率最高，为 19%。结论大动脉缺血性脑卒中患者PAD患病率较高。与有症状的 PAD 和非 PAD 患者相比，无症状的 PAD 具有更大的大动脉缺血性卒中复发和死亡的潜在风险。