An autonomous wearable system for diurnal sweat biomarker data acquisition,Lab on a Chip

当前位置： X-MOL 学术 › Lab Chip › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

An autonomous wearable system for diurnal sweat biomarker data acquisition
Lab on a Chip ( IF 6.1 ) Pub Date : 2020-10-07 , DOI: 10.1039/d0lc00820f
Hannaneh Hojaiji ₁ , Yichao Zhao ₂ , Max C Gong ₁ , Mudith Mallajosyula ₃ , Jiawei Tan ₂ , Haisong Lin ₁ , Amir M Hojaiji ₄ , Shuyu Lin ₁ , Carlos Milla ₅ , Asad M Madni ₆ , Sam Emaminejad ₇

Affiliation

Interconnected and Integrated Bioelectronics Lab (I2BL), Henry Samueli School of Engineering and Applied Science, University of California, Los Angeles, CA, USA. and Department of Electrical and Computer Engineering, University of California, Los Angeles, CA, USA.
Interconnected and Integrated Bioelectronics Lab (I2BL), Henry Samueli School of Engineering and Applied Science, University of California, Los Angeles, CA, USA. and Department of Materials Science and Engineering, University of California, Los Angeles, CA, USA.
Interconnected and Integrated Bioelectronics Lab (I2BL), Henry Samueli School of Engineering and Applied Science, University of California, Los Angeles, CA, USA. and Department of Computer Science and Engineering, University of California, Los Angeles, CA, USA.
Interconnected and Integrated Bioelectronics Lab (I2BL), Henry Samueli School of Engineering and Applied Science, University of California, Los Angeles, CA, USA.
The Stanford Cystic Fibrosis Center, Center for Excellence in Pulmonary Biology, Stanford School of Medicine, Stanford, CA, USA.
Department of Electrical and Computer Engineering, University of California, Los Angeles, CA, USA.
Interconnected and Integrated Bioelectronics Lab (I2BL), Henry Samueli School of Engineering and Applied Science, University of California, Los Angeles, CA, USA. and Department of Electrical and Computer Engineering, University of California, Los Angeles, CA, USA and Department of Bioengineering, University of California, Los Angeles, CA, USA.

To track dynamically varying and physiologically relevant biomarker profiles in sweat, autonomous wearable platforms are required to periodically sample and analyze sweat with minimal or no user intervention. Previously reported sweat sensors are functionally limited to capturing biomarker information at one time-point/period, thereby necessitating repeated user intervention to increase the temporal granularity of biomarker data. Accordingly, we present a compact multi-compartment wearable system, where each compartment can be activated to autonomously induce/modulate sweat secretion (via iontophoretic actuation) and analyze sweat at set time points. This system was developed following a hybrid-flex design and a vertical integration scheme—integrating the required functional modules: miniaturized iontophoresis interfaces, adhesive thin film microfluidic-sensing module, and control/readout electronics. The system was deployed in a human subject study to track the diurnal variation of sweat glucose levels in relation to the daily food intake. The demonstrated autonomous operation for diurnal sweat biomarker data acquisition illustrates the system's suitability for large-scale and longitudinal personal health monitoring applications.

中文翻译：

自主的可穿戴系统，用于昼夜汗液生物标志物数据采集

为了跟踪汗液中的动态变化和生理相关的生物标志物概况，需要自主的可穿戴平台来定期采样和分析汗液，而无需用户干预或干预最少。先前报道的汗液传感器在功能上限于在一个时间点/时间段捕获生物标记信息，从而需要重复的用户干预以增加生物标记数据的时间粒度。因此，我们提出了一个紧凑的多隔室可穿戴系统，其中每个隔室可以被激活以自主诱导/调节汗液分泌（通过离子电渗疗法致动），并在设定的时间点分析汗液。该系统是根据混合柔性设计和垂直集成方案开发的，其中集成了所需的功能模块：小型化的离子电渗疗法接口，粘性薄膜微流体传感模块以及控制/读出电子设备。该系统被部署在一项人体研究中，以追踪与每日食物摄入量有关的汗液葡萄糖水平的日变化。昼夜汗液生物标志物数据采集的演示自主操作说明了该系统对大规模和纵向个人健康监测应用的适用性。

更新日期：2020-11-03

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11