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Tooth desensitizing calcium phosphate composite gelatin-based gel
Journal of Bioactive and Compatible Polymers ( IF 2.1 ) Pub Date : 2020-10-06 , DOI: 10.1177/0883911520960502
Jutharat Waiyawat 1 , Pimchanok Kanjana 1 , Mesayamas Kongsema 2 , Khrongkhwan Akkarachaneeyakorn 1
Affiliation  

Dentine sensitivity is a dental problem common in individuals aged between 20 and 50 years. The most effective treatment method involves occluding the exposed dental tubules. This study focused on the synthesis of calcium phosphate nanoparticles in the form of gel to use as a proof of concept for home-treatment of sensitive teeth. In this study, calcium phosphate nanoparticles were prepared using emulsion method, in which oleic fatty acid was employed as an external phase, and sodium dodecyl sulphate (SDS) was used as a surfactant to form water-in-oil nanodroplets. Finally, in order to facilitate gel formation, the gelatin solution was introduced at the final step. The amount of gelatin varied from 5 to 15 percent by weight, which was found to have an effect on the gels’ properties and the size of calcium phosphate nanoparticles embedded in gel. Based on the characterization, the calcium phosphate nanoparticles were spherical in shape, though the size decreased as the amount of gelatin increased. The gel embedding smallest nanoparticle, that is, gel-15%G, was successfully proven to be non-toxic and able to fully occlude the dentine tubules only after overnight application. According to acid challenge, the occluded materials can resist to acid solution via redissolvation and reprecipitaion process.

中文翻译:

牙齿脱敏磷酸钙复合明胶凝胶

牙本质敏感性是一种常见于 20 至 50 岁人群的牙齿问题。最有效的治疗方法是封闭暴露的牙管。这项研究的重点是合成凝胶形式的磷酸钙纳米颗粒,用作敏感牙齿家庭治疗的概念证明。本研究采用乳化法制备磷酸钙纳米颗粒,其中以油酸脂肪酸为外相,以十二烷基硫酸钠(SDS)为表面活性剂,形成油包水纳米液滴。最后,为了促进凝胶形成,在最后一步加入明胶溶液。明胶的量按重量从 5% 到 15% 不等,发现这会影响凝胶的特性和嵌入凝胶中的磷酸钙纳米颗粒的大小。根据表征,磷酸钙纳米颗粒的形状为球形,但尺寸随着明胶量的增加而减小。凝胶嵌入最小的纳米颗粒,即凝胶-15%G,已被成功证明是无毒的,并且仅在使用过夜后才能完全封闭牙本质小管。根据酸挑战,被吸留的材料可以通过再溶解和再沉淀过程抵抗酸溶液。
更新日期:2020-10-06
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