Polymer-Supported Chiral Cis-Disubstituted Pyrrolidine Catalysts and Their Application to Batch and Continuous-Flow Systems,Organic Process Research & Development

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Polymer-Supported Chiral Cis-Disubstituted Pyrrolidine Catalysts and Their Application to Batch and Continuous-Flow Systems
Organic Process Research & Development ( IF 3.1 ) Pub Date : 2020-10-06 , DOI: 10.1021/acs.oprd.0c00268
Hidenori Ochiai ₁ , Akira Nishiyama ₁ , Naoki Haraguchi ₂ , Shinichi Itsuno ₂

Affiliation

Polymer-supported cis-pyrrolidine catalysts were developed that allowed for high enantioselectivity and diastereoselectivity compared with those obtained from common trans-pyrrolidine catalysts. Not only configurational but also polymeric effects contribute to the high diastereoselectivity and enantioselectivity. Polymer catalysts were also successfully applied in a continuous-flow process. Acceleration of the reaction rate, an increase in diastereoselectivity, and an improvement in durability were observed in continuous-flow operation compared with the batch system.

中文翻译：

聚合物负载的手性顺式-双取代吡咯烷催化剂及其在间歇和连续流系统中的应用

与从普通的反式-吡咯烷催化剂获得的那些相比，开发了聚合物负载的顺式-吡咯烷催化剂，其允许高的对映选择性和非对映选择性。不仅构型效应而且聚合效应也有助于高非对映选择性和对映选择性。聚合物催化剂也成功地应用于连续流工艺中。与间歇式系统相比，在连续流操作中观察到反应速率的加快，非对映选择性的增加和耐久性的提高。

更新日期：2020-10-17

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