The AR signaling pathway plays an important role in initiation and progression of many hormone-related cancers including prostate, bladder, kidney, lung, and breast cancer. However, the potential roles of androgen-responsive long noncoding RNAs (lncRNAs) in hormone-related cancers remained unclear. In the present study, we identified 469 novel androgen-responsive lncRNAs using microarray data. After validating the accuracy of the array data, we constructed a transcriptional network which contained more than 30 transcriptional factors using ChIP-seq data to explore upstream regulators of androgen-responsive lncRNAs. Next, we conducted bioinformatics analysis to identify lncRNA-miRNA-mRNA regulatory network. To explore the potential roles of androgen-responsive lncRNAs in hormone-related cancers, we performed coexpression network and PPI network analyses using TCGA data. GO and KEGG analyses showed these lncRNAs were mainly involved in regulating signal transduction, transcription, development, cell adhesion, immune response, cell differentiation, and MAPK signaling pathway. We also highlight the prognostic value of HPN-AS1, TPTEP1, and LINC00623 in cancer outcomes. Our results suggest that androgen-responsive lncRNAs played important roles in regulating hormone-related cancer progression and could be novel molecular biomarkers.

中文翻译：

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激素相关癌症中雄激素反应性lncRNAs介导的调节网络的全面表征。

AR信号通路在许多与激素有关的癌症（包括前列腺癌，膀胱癌，肾癌，肺癌和乳腺癌）的发生和发展中起着重要作用。然而，尚不清楚雄激素反应性长非编码RNA（lncRNA）在激素相关癌症中的潜在作用。在本研究中，我们使用微阵列数据鉴定了469种新颖的雄激素反应性lncRNA。验证阵列数据的准确性后，我们使用ChIP-seq数据构建了一个包含30多个转录因子的转录网络，以探索雄激素反应性lncRNA的上游调节子。接下来，我们进行了生物信息学分析，以鉴定lncRNA-miRNA-mRNA调控网络。为了探索雄激素反应性lncRNA在激素相关癌症中的潜在作用，我们使用TCGA数据进行了共表达网络和PPI网络分析。GO和KEGG分析表明，这些lncRNA主要参与调节信号转导，转录，发育，细胞粘附，免疫应答，细胞分化和MAPK信号通路。我们还强调了HPN-AS1，TPTEP1和LINC00623在癌症预后中的预后价值。我们的研究结果表明雄激素响应lncRNA在调节激素相关的癌症进展中起重要作用，并且可能是新型的分子生物标记。和LINC00623在癌症预后方面。我们的研究结果表明雄激素响应lncRNA在调节激素相关的癌症进展中起重要作用，并且可能是新型的分子生物标记。和LINC00623在癌症预后方面。我们的研究结果表明雄激素响应lncRNA在调节激素相关的癌症进展中起重要作用，并且可能是新型的分子生物标记。