Polypharmacology or “Pharmacological Promiscuity” In Psychedelic Research: What Are We Missing?,ACS Chemical Neuroscience

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Polypharmacology or “Pharmacological Promiscuity” In Psychedelic Research: What Are We Missing?
ACS Chemical Neuroscience ( IF 4.1 ) Pub Date : 2020-10-06 , DOI: 10.1021/acschemneuro.0c00614
Genı S Ona _{1,

2} , Rafael G Dos Santos _{1,

3,

4} , Jaime E C Hallak _{3,

4} , José Carlos Bouso _{1,

2}

Affiliation

Research with psychedelic drugs has mainly focused on isolated compounds. However, this approach is challenged by the “polypharmacology” paradigm. In this Viewpoint, we suggest that we may be missing something if we do not use the whole product in the case of ayahuasca or Psilocybe mushrooms. After describing how research on psychedelic drugs can be effectively combined with the polypharmacology paradigm, ethical issues are also briefly discussed.

中文翻译：

迷幻研究中的多药理学或“药理学滥交”：我们缺少什么？

迷幻药的研究主要集中在分离的化合物上。但是，这种方法受到“多元药理学”范式的挑战。在这种观点下，我们建议，如果我们没有使用整个产品，则对于ayahuasca或Psilocybe蘑菇，可能会缺少一些东西。在描述了如何将迷幻药物的研究与多药理学范式有效结合后，还简要讨论了伦理问题。

更新日期：2020-10-21

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