Abstract

Purpose

This study was carried out to investigate the relationship of pain, anxiety, and fatigue with position sense, balance, and dual task performance during the menstrual cycle in females with multiple sclerosis.

Methods

This study included 14 females with multiple sclerosis with regular menstrual cycles. The individuals' position sense, balance, and dual task performance were evaluated with a digital inclinometer, Biodex Balance System, and the Time Up and Go Test, respectively. Pain, anxiety, and fatigue were assessed with the Visual Analogue Scale, State-Trait Anxiety Inventory, and Fatigue Severity Scale, respectively. The study protocol was registered at http://clinicaltrials.gov (NCT04408742).

Results

In the early follicular phase, the pain was correlated with right knee position sense, and pain + activity was correlated with right knee position sense and dual task performance (p < .05). The correlation analysis revealed that no correlation was found between pain, pain + activity, anxiety, and fatigue, and position sense, balance, and dual task performance in the ovulation phase. In the luteal phase, the right knee position sense was correlated with pain, pain + activity, and fatigue (p < .05). Similarly, the left knee position sense was correlated with pain, pain + activity, and fatigue (p < .05).

Conclusions

As a result, there may be a relationship between pain and position sense in the early follicular phase and luteal phase, and a relationship between pain and motor dual task performance in the early follicular phase. Considering these changes occurring in different phases of the menstrual cycle, we think that each phase of the menstrual cycle should be taken into consideration in the follow-up of physiotherapy evaluations in females with multiple sclerosis. Abbreviations: MS: multiple sclerosis; CNS: central nervous system; FwMS: females with multiple sclerosis; eFP: early follicular phase; OP: ovulation phase; LP: luteal phase

中文翻译：

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多发性硬化女性月经周期疼痛、焦虑和疲劳与膝关节位置感、平衡和双重任务表现的关系

摘要

目的

本研究旨在探讨多发性硬化症女性在月经周期中疼痛、焦虑和疲劳与位置感、平衡和双重任务表现的关系。

方法

该研究包括 14 名患有多发性硬化症且月经周期规律的女性。分别使用数字倾角仪、Biodex 平衡系统和 Time Up and Go Test 评估个人的位置感、平衡和双重任务表现。疼痛、焦虑和疲劳分别用视觉模拟量表、状态-特质焦虑量表和疲劳严重度量表进行评估。研究方案已在 http://clinicaltrials.gov (NCT04408742) 上注册。

结果

在卵泡早期，疼痛与右膝位置感相关，疼痛+活动与右膝位置感和双任务表现相关（p  < .05）。相关性分析显示，排卵期疼痛、疼痛+活动、焦虑和疲劳与位置感、平衡和双重任务表现之间没有发现相关性。在黄体期，右膝位置感与疼痛、疼痛 + 活动和疲劳相关 ( p  < .05)。同样，左膝位置感与疼痛、疼痛 + 活动和疲劳相关 ( p  < .05)。

结论

因此，可能存在卵泡早期和黄体期疼痛与位置感的关系，卵泡早期疼痛与运动双任务表现之间的关系。考虑到这些变化发生在月经周期的不同阶段，我们认为在对患有多发性硬化症的女性​​进行物理治疗评估的后续过程中，应考虑到月经周期的每个阶段。缩写： MS：多发性硬化症；CNS：中枢神经系统；FwMS：患有多发性硬化症的女性​​；eFP：早期卵泡期；OP：排卵期；LP：黄体期