Abstract The objective of this meta-analysis was to estimate the association of ACE I/D, −240 A > T and AT1R 1166 A > C polymorphisms with breast cancer (BC) risk. A comprehensive search on databases was conducted to identify all eligible case-control studies. Finally, 35 case-control studies, including 20 studies for ACE I/D, seven studies for ACE 240 A > T, and eight studies for AT1R 1166 A > C were included. The pooled analysis showed a significant association between ACE I/D polymorphism and BC risk under three genetic models, i.e., heterozygote (ID vs. DD: OR = 0.707, 95% CI 0.528-0.946, p = 0.020), homozygote (II vs. DD: OR = 0.662, 95% CI 0.462-0.947, p = 0.024), and dominant (II + ID vs. DD: OR = 0.691, 95% CI 0.507-0.941, p = 0.019). A significant association was also observed in ACE I/D polymorphism with BC risk among Asians and Caucasians. However, ACE −240 A > T and AT1R 1166 A > C polymorphisms were not associated with BC. Stratified analyses by ethnicity showed a significant association of ACE −240 A > T and AT1R 1166 A > C polymorphisms with BC risk in Latinos populations, but not in Asians. This meta-analysis inconsistence with all previous meta-analyses suggests that the ACE I/D might be associated with BC in overall and by ethnicity. However, the ACE −240 A > T and AT1R 1166 A > C were associated with BC risk only among Latinos populations.

中文翻译：

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ACE I/D、-240A > T 和 AT1R A1166C 多态性与乳腺癌易感性的关联：基于 35 个病例对照研究的系统评价和荟萃分析

摘要 本荟萃分析的目的是评估 ACE I/D、-240 A > T 和 AT1R 1166 A > C 多态性与乳腺癌 (BC) 风险的关联。对数据库进行了全面搜索，以确定所有符合条件的病例对照研究。最后，纳入了 35 项病例对照研究，包括 20 项针对 ACE I/D 的研究、7 项针对 ACE 240 A > T 的研究和 8 项针对 AT1R 1166 A > C 的研究。汇总分析显示，ACE I/D 多态性与 BC 风险在三种遗传模型下存在显着关联，即杂合子（ID 与 DD：OR = 0.707，95% CI 0.528-0.946，p = 0.020）、纯合子（II 与 DD： DD：OR = 0.662，95% CI 0.462-0.947，p = 0.024），显性（II + ID vs. DD：OR = 0.691，95% CI 0.507-0.941，p = 0.019）。在亚洲人和高加索人的 ACE I/D 多态性与 BC 风险中也观察到显着关联。然而，ACE -240 A > T 和 AT1R 1166 A > C 多态性与 BC 无关。按种族进行的分层分析显示，ACE -240 A > T 和 AT1R 1166 A > C 多态性与拉丁裔人群的 BC 风险显着相关，但在亚洲人中则不然。这种与之前所有荟萃分析不一致的荟萃分析表明，ACE I/D 可能在整体上和种族上与 BC 相关。然而，ACE -240 A > T 和 AT1R 1166 A > C 仅在拉丁裔人群中与 BC 风险相关。T 和 AT1R 1166 A > C 多态性在拉丁裔人群中具有 BC 风险，但在亚洲人群中不存在。这种与之前所有荟萃分析不一致的荟萃分析表明，ACE I/D 可能在整体上和种族上与 BC 相关。然而，ACE -240 A > T 和 AT1R 1166 A > C 仅在拉丁裔人群中与 BC 风险相关。T 和 AT1R 1166 A > C 多态性在拉丁裔人群中具有 BC 风险，但在亚洲人群中不存在。这种与之前所有荟萃分析不一致的荟萃分析表明，ACE I/D 可能在整体上和种族上与 BC 相关。然而，ACE -240 A > T 和 AT1R 1166 A > C 仅在拉丁裔人群中与 BC 风险相关。