Active vision is a fundamental process by which primates gather information about the external world. Multiple brain regions have been studied in the context of simple active vision tasks in which a visual target's appearance is temporally separated from saccade execution. Most neurons have tight spatial registration between visual and saccadic signals, and in areas such as prefrontal cortex (PFC) some neurons show persistent delay activity that links visual and motor epochs and has been proposed as a basis for spatial working memory. Many PFC neurons also show rich dynamics, which have been attributed to alternative working memory codes and the representation of other task variables. Our study investigated the transition between processing a visual stimulus and generating an eye movement in populations of PFC neurons in macaque monkeys performing a memory guided saccade task. We found that neurons in two subregions of PFC, the frontal eye fields (FEF) and area 8Ar, differed in their dynamics and spatial response profiles. These dynamics could be attributed largely to shifts in the spatial profile of visual and motor responses in individual neurons. This led to visual and motor codes for particular spatial locations that were instantiated by different mixtures of neurons, which could be important in PFC's flexible role in multiple sensory, cognitive, and motor tasks.

中文翻译：

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前额叶皮层区域 8Ar 和 FEF 中视觉和扫视信号的动态变化

主动视觉是灵长类动物收集外部世界信息的基本过程。已经在简单的主动视觉任务的背景下研究了多个大脑区域，其中视觉目标的外观在时间上与扫视执行分开。大多数神经元在视觉和扫视信号之间具有紧密的空间记录，并且在前额叶皮层 (PFC) 等区域，一些神经元表现出持续的延迟活动，将视觉和运动时期联系起来，并已被提议作为空间工作记忆的基础。许多 PFC 神经元也表现出丰富的动态，这归因于替代工作记忆代码和其他任务变量的表示。我们的研究调查了在执行记忆引导扫视任务的猕猴 PFC 神经元群体中处理视觉刺激和产生眼球运动之间的转变。我们发现 PFC 的两个子区域中的神经元，即额叶眼场 (FEF) 和 8Ar 区域，其动力学和空间响应曲线不同。这些动态可能主要归因于单个神经元中视觉和运动反应的空间分布的变化。这导致了由不同神经元混合实例化的特定空间位置的视觉和运动代码，这对于 PFC 在多种感觉、认知和运动任务中的灵活作用可能很重要。它们的动力学和空间响应曲线不同。这些动态可能主要归因于单个神经元中视觉和运动反应的空间分布的变化。这导致了由不同神经元混合实例化的特定空间位置的视觉和运动代码，这对于 PFC 在多种感觉、认知和运动任务中的灵活作用可能很重要。它们的动力学和空间响应曲线不同。这些动态可能主要归因于单个神经元中视觉和运动反应的空间分布的变化。这导致了由不同神经元混合实例化的特定空间位置的视觉和运动代码，这对于 PFC 在多种感觉、认知和运动任务中的灵活作用可能很重要。