Inertial microfluidics has attracted significant attentions in last decade due to its superior advantages of high throughput, label‐ and external field‐free operation, simplicity, and low cost. A wide variety of channel geometry designs were demonstrated for focusing, concentrating, isolating, or separating of various bioparticles such as blood components, circulating tumor cells, bacteria, and microalgae. In this review, we first briefly introduce the physics of inertial migration and Dean flow for allowing the readers with diverse backgrounds to have a better understanding of the fundamental mechanisms of inertial microfluidics. Then, we present a comprehensive review of the recent advances and applications of inertial microfluidic devices according to different channel geometries ranging from straight channels, curved channels to contraction‐expansion‐array channels. Finally, the challenges and future perspective of inertial microfluidics are discussed. Owing to its superior benefit for particle manipulation, the inertial microfluidics will play a more important role in biology and medicine applications.

中文翻译：

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惯性微流体：最新进展


惯性微流控由于其高通量、无标记和无外部场操作、简单和低成本的优越优势在过去十年中引起了广泛的关注。多种通道几何设计被证明可用于聚焦、浓缩、隔离或分离各种生物颗粒，例如血液成分、循环肿瘤细胞、细菌和微藻。在这篇综述中，我们首先简要介绍惯性迁移和迪安流的物理原理，以便让不同背景的读者更好地理解惯性微流控的基本机制。然后，我们根据不同的通道几何形状，从直通道、弯曲通道到收缩-膨胀阵列通道，全面回顾了惯性微流控装置的最新进展和应用。最后，讨论了惯性微流控的挑战和未来前景。由于惯性微流控在粒子操纵方面的优越性，它将在生物学和医学应用中发挥更重要的作用。