PRKAR2B‐HIF‐1α loop promotes aerobic glycolysis and tumour growth in prostate cancer,Cell Proliferation

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PRKAR2B‐HIF‐1α loop promotes aerobic glycolysis and tumour growth in prostate cancer
Cell Proliferation ( IF 5.9 ) Pub Date : 2020-10-07 , DOI: 10.1111/cpr.12918
Lei Xia ₁ , Jian Sun ₂ , Shaowei Xie ₃ , Chenfei Chi ₁ , Yinjie Zhu ₁ , Jiahua Pan ₁ , Baijun Dong ₁ , Yiran Huang ₁ , Weiliang Xia ₄ , Jianjun Sha ₁ , Wei Xue ₁

Affiliation

Reprogramming of cellular metabolism is profoundly implicated in tumorigenesis and can be exploited to cancer treatment. Cancer cells are known for their propensity to use glucose‐dependent glycolytic pathway instead of mitochondrial oxidative phosphorylation for energy generation even in the presence of oxygen, a phenomenon known as Warburg effect. The type II beta regulatory subunit of protein kinase A (PKA), PRKAR2B, is highly expressed in castration‐resistant prostate cancer (CRPC) and contributes to tumour growth and metastasis. However, whether PRKAR2B regulates glucose metabolism in prostate cancer remains largely unknown.

中文翻译：

PRKAR2B-HIF-1α环促进前列腺癌的有氧糖酵解和肿瘤生长

细胞代谢的重编程与肿瘤发生密切相关，可用于癌症治疗。众所周知，即使在有氧存在的情况下，癌细胞也倾向于使用葡萄糖依赖性糖酵解途径而不是线粒体氧化磷酸化来产生能量，这种现象被称为瓦伯格效应。蛋白激酶 A (PKA) 的 II 型 β 调节亚基 PRKAR2B 在去势抵抗性前列腺癌 (CRPC) 中高表达，有助于肿瘤生长和转移。然而，PRKAR2B 是否调节前列腺癌中的葡萄糖代谢仍然很大程度上未知。

更新日期：2020-10-07

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