In vivo sun protection factor and UVA protection factor determination using (hybrid) diffuse reflectance spectroscopy and a multi‐lambda‐LED light source,Journal of Biophotonics

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In vivo sun protection factor and UVA protection factor determination using (hybrid) diffuse reflectance spectroscopy and a multi‐lambda‐LED light source
Journal of Biophotonics ( IF 2.0 ) Pub Date : 2020-10-06 , DOI: 10.1002/jbio.202000348
Carolin Maria Throm ₁ , Georg Wiora ₂ , Carina Reble ₂ , Johannes Schleusener ₁ , Sabine Schanzer ₁ , Hans Karrer ₃ , Ludger Kolbe ₄ , Georg Khazaka ₂ , Martina C Meinke ₁ , Jürgen Lademann ₁

Affiliation

The sun protection factor (SPF) values are currently determined using an invasive procedure, in which the volunteers are irradiated with ultraviolet (UV) light. Non‐invasive approaches based on hybrid diffuse reflectance spectroscopy (HDRS) have shown a good correlation with conventional SPF testing. Here, we present a novel compact and adjustable DRS test system. The in vivo measurements were performed using a multi‐lambda‐LED light source and an 84‐channel imaging spectrograph with a fiber optic probe for detection. A transmission spectrum was calculated based on the reflectance measured with sunscreen and the reflectance measured without sunscreen. The preexposure in vitro spectrum was fitted to the in vivo spectrum. Each of the 11 test products was investigated on 10 volunteers. The SPF and UVA‐PF values obtained by this new approach were compared with in vivo SPF results determined by certified test institutes. A correlation coefficient R² = 0.86 for SPF, and R² = 0.92 for UVA‐PF were calculated. Having examined various approaches to apply the HDRS principle, the method we present was found to produce valid and reproducible results, suggesting that the multi‐lambda‐LED device is suitable for in‐vivo SPF testing based on the HDRS principle as well as for in‐vivo UVA‐PF measurements.

中文翻译：

使用（混合）漫反射光谱法和多λLED光源确定体内防晒系数和UVA防护系数

当前，使用侵入性程序确定防晒系数（SPF）值，其中用紫外线（UV）照射志愿者。基于混合漫反射光谱（HDRS）的非侵入性方法已显示出与常规SPF测试的良好相关性。在这里，我们介绍了一种新颖的紧凑型可调DRS测试系统。使用多λLED光源和带有光纤探头进行检测的84通道成像光谱仪进行体内测量。基于使用防晒霜测量的反射率和不使用防晒霜测量的反射率来计算透射光谱。暴露前的体外光谱适合于体内光谱。在10名志愿者中对11种测试产品中的每一种进行了调查。将通过这种新方法获得的SPF和UVA-PF值与认证测试机构确定的体内SPF结果进行比较。相关系数RSPF的² = 0.86，UVA-PF的R ² = 0.92。研究了应用HDRS原理的各种方法后，我们发现的方法可产生有效且可重现的结果，这表明该多层LED器件适用于基于HDRS原理的体内SPF测试以及用于体内UVA-PF测量。

更新日期：2020-10-06

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