Acquisition of human plasminogen facilitates complement evasion by the malaria parasite Plasmodium falciparum,European Journal of Immunology

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Acquisition of human plasminogen facilitates complement evasion by the malaria parasite Plasmodium falciparum
European Journal of Immunology ( IF 4.5 ) Pub Date : 2020-10-06 , DOI: 10.1002/eji.202048718
Timo Reiss ₁ , Hannah I. Theis ₁ , Andres Gonzalez‐Delgado ₂ , Joel Vega‐Rodriguez ₃ , Peter F. Zipfel ₂ , Christine Skerka ₂ , Gabriele Pradel ₁

Affiliation

We show that the intraerythrocytic stages of the malaria parasite Plasmodium falciparum bind plasminogen and mediate its conversion into plasmin to inactivate parasite‐bound C3b. This complement evasion mechanism counteracts terminal complex formation and hence promotes parasite survival in human blood.