Standardized microfluidic assessment of red blood cell–mediated microcapillary occlusion: Association with clinical phenotype and hydroxyurea responsiveness in sickle cell disease,Microcirculation

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Standardized microfluidic assessment of red blood cell–mediated microcapillary occlusion: Association with clinical phenotype and hydroxyurea responsiveness in sickle cell disease
Microcirculation ( IF 2.4 ) Pub Date : 2020-10-06 , DOI: 10.1111/micc.12662
Yuncheng Man ₁ , Erdem Kucukal ₁ , Ran An ₁ , Allison Bode _{1,

2} , Jane A Little ₃ , Umut A Gurkan _{1,

4}

Affiliation

We present a standardized in vitro microfluidic assay and Occlusion Index (OI) for the assessment of red blood cell (RBC)–mediated microcapillary occlusion and its clinical associations in sickle cell disease (SCD).

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