Immunobiology and immunotherapy of COVID‐19: A clinically updated overview,Journal of Cellular Physiology

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Immunobiology and immunotherapy of COVID‐19: A clinically updated overview
Journal of Cellular Physiology ( IF 4.5 ) Pub Date : 2020-10-06 , DOI: 10.1002/jcp.30076
Abdolreza Esmaeilzadeh _{1,

2,

3} , Reza Elahi ₄

Affiliation

Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is a new member of the coronavirus family that can cause coronavirus disease 2019 (COVID‐19). COVID‐9 has become a global pandemic with severe health issues around the world. Identifying the accurate immunopathogenesis of the COVID‐19 and the immune response against SARS‐CoV‐2 is necessary for the development of therapeutic approaches and rational drug design. This paper aims to overview the updated clinical data on the immunopathogenesis of the COVID‐19 and review the innate and adaptive immune response to SARS‐CoV‐2. Also, challenges of the immune response to SARS‐CoV‐2 leading to dysfunctional immune response and their contribution to the progression of the disease have been discussed. To achieve a more efficient immune response, multiple methods could be applied, including regulation of the immune response, augmentation of the immune system against the virus, inhibition of the dysfunctional immune checkpoints, and inhibition of the viral replication/infection. Based on the immune response against SARS‐CoV‐2 and its dysfunction, we introduce potential immunotherapies as well as reviewing recruiting/completed clinical trials of COVID‐19.

中文翻译：

COVID-19 的免疫生物学和免疫治疗：临床更新概述

严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 是冠状病毒家族的新成员，可引起 2019 年冠状病毒病 (COVID-19)。 COVID-9 已成为全球流行病，在世界各地带来严重的健康问题。准确识别 COVID-19 的免疫发病机制和针对 SARS-CoV-2 的免疫反应对于开发治疗方法和合理的药物设计是必要的。本文旨在概述有关 COVID-19 免疫发病机制的最新临床数据，并回顾对 SARS-CoV-2 的先天性和适应性免疫反应。此外，还讨论了针对 SARS-CoV-2 的免疫反应带来的挑战，导致免疫反应功能失调及其对疾病进展的贡献。为了实现更有效的免疫反应，可以应用多种方法，包括调节免疫反应、增强针对病毒的免疫系统、抑制功能失调的免疫检查点以及抑制病毒复制/感染。基于针对 SARS-CoV-2 的免疫反应及其功能障碍，我们介绍了潜在的免疫疗法，并回顾了 COVID-19 的招募/已完成的临床试验。

更新日期：2020-10-06

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