Substance use disorders pose a common medical, social and financial problem. Among the pathomechanisms of substance use disorders, the disruption and increased permeability of the blood-brain barrier has been recently revealed. Physical exercise appears to be a relatively inexpensive and feasible way to implement behavioral therapy counteracting the blood-brain barrier impairment. Concomitantly, there are also studies supporting a potential protective role of selected substances of abuse in maintaining the blood-brain barrier integrity. In this review, we aim to provide a summary on the modulatory influence of physical exercise, a non-pharmacological intervention, on the blood-brain barrier alterations caused by substances of abuse. Further studies are needed to understand the precise mechanisms that underlie various effects of physical exercise in substance use disorders.

物质使用障碍构成普遍的医疗，社会和经济问题。在物质使用障碍的发病机制中，最近已经揭示了血脑屏障的破坏和通透性的增加。体育锻炼似乎是一种相对便宜且可行的方法，可用于采取行为疗法来抵消血脑屏障损害。同时，也有研究支持某些滥用物质在维持血脑屏障完整性方面的潜在保护作用。在这篇综述中，我们旨在总结体育锻炼（一种非药物干预）对滥用药物引起的血脑屏障改变的调节作用的总结。