Plexitis in the proximal margin of intestinal resections are associated with post-operative recurrence of Crohn's disease. To understand their formation, in vitro analyzes were performed. T cells adhered preferentially to neuron and glial cells in mixed primary cultures of enteric nervous system and T cell activation increased their adhesion capacity. Higher number of T lymphocytes in close proximity to enteric glial cells was also observed in the myenteric ganglia of Crohn's patients as compared to control. These data show that close proximity between lymphocytes and enteric neural cells exists and may contribute to the formation of plexitis.

中文翻译：

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T 细胞在培养中表现出对肠神经细胞的优先粘附，并且靠近克罗恩病患者肌间神经节中的神经细胞。

肠切除术近端边缘的丛炎与克罗恩病的术后复发有关。为了了解它们的形成，进行了体外分析。在肠神经系统的混合原代培养物中，T 细胞优先粘附于神经元和神经胶质细胞，T 细胞活化增加了它们的粘附能力。与对照相比，在克罗恩病患者的肌间神经节中也观察到了靠近肠神经胶质细胞的更高数量的 T 淋巴细胞。这些数据表明淋巴细胞和肠神经细胞之间存在紧密的接近，并且可能导致丛炎的形成。